Interactive effecs of mechano- and chemo-receptor inputs on cardiorespiratory outputs in the toad

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

Arterial blood pressure (P-b), pulmocutaneous blood flow (Q(pc)), heart rate (f(H)), and fictive ventilation (motor activity in the Vth cranial nerve, V-int), were recorded front decerebrated, paralysed toads receiving unidirectional ventilation with experimental gas mixtures over a range Of lung inflation. At the onset of spontaneous bouts of fictive ventilation, Q(pc) and P-p, increased immediately, often with changes in heart rate, implying central cardiorespiratory interactions. Inflation of the lungs with different gas mixtures revealed that the effect of hypercarbia on V-int was reduced by lung inflation and that feedback from Pulmonary stretch receptors may summate with central feedforward control of f(H) and Q(pc) in an interactive fashion. The results of bolus injections of cyanide into the carotid or the pulmonary Circulations Suggest there are oxygen sensitive receptors in both circuits that affect the cardiovascular system directly and respiratory activity by complex central interactions with inputs from central chemoreceptors and pulmonary stretch receptors. (C) 2004 Elsevier B.V. All rights reserved.

Details

Original languageEnglish
Pages (from-to)63-76
Number of pages14
JournalRespiratory physiology & neurobiology
Volume140
Publication statusPublished - 1 Jan 2004

Keywords

  • control of breathing, interaction mechano, chemosensors, pattern of breathing, hypoxia, hypercapnia, hypercapnia, pattern of breathing, receptors, pulmonary stretch, amphibian, toad (Bufo marinus), hypoxia, pattern of breathing, arterial chemo, blood flow, pulmocutaneous