Interactions between the juvenile Batten disease gene, CLN3, and the Notch and JNK signalling pathways

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Authors

Abstract

Mutations in the gene CLN3 are responsible for the neurodegenerative disorder juvenile neuronal ceroid lipofuscinosis or Batten disease. CLN3 encodes a multi-spanning and hydrophobic transmembrane protein whose function is unclear. As a consequence, the cell biology that underlies the pathology of the disease is not well understood. We have developed a genetic gain-of-function system in Drosophila to identify functional pathways and interactions for CLN3. We have identified previously unknown interactions between CLN3 and the Notch and Jun N-terminal kinase signalling pathways and have uncovered a potential role for the RNA splicing and localization machinery in regulating CLN3 function.

Details

Original languageEnglish
Pages (from-to)667-78
Number of pages12
JournalHuman Molecular Genetics
Volume18
Issue number4
Publication statusPublished - 2009