Interactions between metabolic, reward and cognitive processes in appetite control: implications for novel weight management therapies

Research output: Contribution to journalArticlepeer-review


  • Michelle Lee
  • Manfred Hallschmid
  • Colin Trevor Dourish


Traditional models of appetite control have emphasised the role of parallel homeostatic and hedonic systems, but more recently the distinction between independent homeostatic and hedonic systems has been abandoned in favour of a framework that emphasises the cross talk between the neurochemical substrates of the two systems. In addition, evidence has emerged more recently, that higher level cognitive functions such as learning, memory and attention play an important role in everyday appetite control and that homeostatic signals also play a role in cognition. Here, we review this evidence and present a comprehensive model of the control of appetite that integrates cognitive, homeostatic and reward mechanisms. We discuss the implications of this model for understanding the factors that may contribute to disordered patterns of eating and suggest opportunities for developing more effective treatment approaches for eating disorders and weight management.


Original languageEnglish
Pages (from-to)1460-1474
JournalJournal of Psychopharmacology
Issue number11
Early online date26 Oct 2017
Publication statusPublished - 1 Nov 2017


  • Food reward, cognition, metabolic signals, appetite control