Intensity-modulated arc therapy to improve radiation dose delivery in the treatment of abdominal neuroblastoma

Jennifer E Gains; Christopher Stacey; Ivan Rosenberg; Henry C Mandeville; Yen-Ch'ing Chang; Derek D'Souza; Veronica Moroz; Keith Wheatley; Mark N Gaze

doi:10.2217/fon.12.199

Intensity-modulated arc therapy to improve radiation dose delivery in the treatment of abdominal neuroblastoma

Jennifer E Gains, Christopher Stacey, Ivan Rosenberg, Henry C Mandeville, Yen-Ch'ing Chang, Derek D'Souza, Veronica Moroz, Keith Wheatley, Mark N Gaze

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The standard European radiotherapy technique for children with neuroblastoma is a conventional parallel opposed pair. This frequently results in compromise on planning target volume coverage to stay within normal tissue tolerances. This study investigates the use of an intensity-modulated arc therapy (IMAT) technique to improve dose distribution and allow better protocol compliance. Among 20 previously treated patients, ten had received the full prescribed dose with conventional planning (protocol compliant) and ten had a compromise on planning target volume coverage (protocol noncompliant). All patients were replanned with IMAT. Dosimetric parameters of the conventional radiotherapy and IMAT were compared. The dose received by 98% of the planning target volume, homogeneity and conformity indices were all improved with IMAT (p < 0.001). IMAT would have enabled delivery of the full protocol dose in eight out of ten protocol-noncompliant patients. IMAT may improve outcomes through improved protocol compliance and better dose distributions.

Original language	English
Pages (from-to)	439-49
Number of pages	11
Journal	Future Oncology
Volume	9
Issue number	3
DOIs	https://doi.org/10.2217/fon.12.199
Publication status	Published - Mar 2013

Keywords

Abdominal Neoplasms
Child
Child, Preschool
Dose Fractionation
Female
Humans
Infant
Male
Neuroblastoma
Quality Improvement
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Intensity-Modulated
Retrospective Studies
Treatment Outcome
Tumor Burden

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title = "Intensity-modulated arc therapy to improve radiation dose delivery in the treatment of abdominal neuroblastoma",

abstract = "The standard European radiotherapy technique for children with neuroblastoma is a conventional parallel opposed pair. This frequently results in compromise on planning target volume coverage to stay within normal tissue tolerances. This study investigates the use of an intensity-modulated arc therapy (IMAT) technique to improve dose distribution and allow better protocol compliance. Among 20 previously treated patients, ten had received the full prescribed dose with conventional planning (protocol compliant) and ten had a compromise on planning target volume coverage (protocol noncompliant). All patients were replanned with IMAT. Dosimetric parameters of the conventional radiotherapy and IMAT were compared. The dose received by 98% of the planning target volume, homogeneity and conformity indices were all improved with IMAT (p < 0.001). IMAT would have enabled delivery of the full protocol dose in eight out of ten protocol-noncompliant patients. IMAT may improve outcomes through improved protocol compliance and better dose distributions.",

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author = "Gains, {Jennifer E} and Christopher Stacey and Ivan Rosenberg and Mandeville, {Henry C} and Yen-Ch'ing Chang and Derek D'Souza and Veronica Moroz and Keith Wheatley and Gaze, {Mark N}",

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AU - Gains, Jennifer E

AU - Stacey, Christopher

AU - Rosenberg, Ivan

AU - Mandeville, Henry C

AU - Chang, Yen-Ch'ing

AU - D'Souza, Derek

AU - Moroz, Veronica

AU - Wheatley, Keith

AU - Gaze, Mark N

PY - 2013/3

Y1 - 2013/3

N2 - The standard European radiotherapy technique for children with neuroblastoma is a conventional parallel opposed pair. This frequently results in compromise on planning target volume coverage to stay within normal tissue tolerances. This study investigates the use of an intensity-modulated arc therapy (IMAT) technique to improve dose distribution and allow better protocol compliance. Among 20 previously treated patients, ten had received the full prescribed dose with conventional planning (protocol compliant) and ten had a compromise on planning target volume coverage (protocol noncompliant). All patients were replanned with IMAT. Dosimetric parameters of the conventional radiotherapy and IMAT were compared. The dose received by 98% of the planning target volume, homogeneity and conformity indices were all improved with IMAT (p < 0.001). IMAT would have enabled delivery of the full protocol dose in eight out of ten protocol-noncompliant patients. IMAT may improve outcomes through improved protocol compliance and better dose distributions.

AB - The standard European radiotherapy technique for children with neuroblastoma is a conventional parallel opposed pair. This frequently results in compromise on planning target volume coverage to stay within normal tissue tolerances. This study investigates the use of an intensity-modulated arc therapy (IMAT) technique to improve dose distribution and allow better protocol compliance. Among 20 previously treated patients, ten had received the full prescribed dose with conventional planning (protocol compliant) and ten had a compromise on planning target volume coverage (protocol noncompliant). All patients were replanned with IMAT. Dosimetric parameters of the conventional radiotherapy and IMAT were compared. The dose received by 98% of the planning target volume, homogeneity and conformity indices were all improved with IMAT (p < 0.001). IMAT would have enabled delivery of the full protocol dose in eight out of ten protocol-noncompliant patients. IMAT may improve outcomes through improved protocol compliance and better dose distributions.

KW - Abdominal Neoplasms

KW - Child

KW - Child, Preschool

KW - Dose Fractionation

KW - Female

KW - Humans

KW - Infant

KW - Male

KW - Neuroblastoma

KW - Quality Improvement

KW - Radiotherapy Planning, Computer-Assisted

KW - Radiotherapy, Intensity-Modulated

KW - Retrospective Studies

KW - Treatment Outcome

KW - Tumor Burden

U2 - 10.2217/fon.12.199

DO - 10.2217/fon.12.199

M3 - Article

C2 - 23469979

SN - 1479-6694

VL - 9

SP - 439

EP - 449

JO - Future Oncology

JF - Future Oncology

IS - 3

ER -

Intensity-modulated arc therapy to improve radiation dose delivery in the treatment of abdominal neuroblastoma

Abstract

Keywords

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