TY - JOUR
T1 - Insulin protects against type 1 diabetes mellitus-induced aortopathy associated with the inhibition of biomarkers of vascular injury in rats
AU - Bin-Jaliaha, Ismaeel
AU - Hewett, Peter
AU - Al Hashem, Fahaid
AU - Haidara, Mohamed
AU - Abdel Kader, Dina
AU - Morsy, M. D.
AU - Al-Ani, Bahjat
PY - 2019/6/28
Y1 - 2019/6/28
N2 - Background: We sought to investigate the protective effect of insulin against type 1 diabetes mellitus (T1DM)-induced aortic injury (aortopathy) associated with the inhibition of biomarkers of vascular injury. Material and methods: T1DM was induced in rats by streptozotocin (STZ) (65 mg/kg), and the protection group started insulin treatment 2 days post diabetic induction and continued until being sacrificed at week 8. Results: Aortopathy was developed in the diabetic rats as demonstrated by profound alterations to the aorta ultrastructure, which was substantially protected by insulin. In addition, insulin significantly inhibited diabetes-induced dyslipidaemia, soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1), oxidative stress, and inflammation. However, blood levels of these biomarkers in the insulin-treated group were still significant (p <.05) compared with the control group, whereas insulin treatment returned blood glucose and triglyceride to control levels. Conclusions: We demonstrate effective protection by insulin against T1DM-induced aortopathy in rats, which is associated with the inhibition of vascular injury biomarkers.
AB - Background: We sought to investigate the protective effect of insulin against type 1 diabetes mellitus (T1DM)-induced aortic injury (aortopathy) associated with the inhibition of biomarkers of vascular injury. Material and methods: T1DM was induced in rats by streptozotocin (STZ) (65 mg/kg), and the protection group started insulin treatment 2 days post diabetic induction and continued until being sacrificed at week 8. Results: Aortopathy was developed in the diabetic rats as demonstrated by profound alterations to the aorta ultrastructure, which was substantially protected by insulin. In addition, insulin significantly inhibited diabetes-induced dyslipidaemia, soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1), oxidative stress, and inflammation. However, blood levels of these biomarkers in the insulin-treated group were still significant (p <.05) compared with the control group, whereas insulin treatment returned blood glucose and triglyceride to control levels. Conclusions: We demonstrate effective protection by insulin against T1DM-induced aortopathy in rats, which is associated with the inhibition of vascular injury biomarkers.
KW - Aortopathy
KW - insulin
KW - rat model
KW - type 1 diabetes mellitus
KW - vascular activation
UR - http://www.scopus.com/inward/record.url?scp=85068204210&partnerID=8YFLogxK
U2 - 10.1080/13813455.2019.1632900
DO - 10.1080/13813455.2019.1632900
M3 - Article
SN - 1381-3455
JO - Archives of Physiology and Biochemistry
JF - Archives of Physiology and Biochemistry
ER -