TY - JOUR
T1 - Inositol phosphates: a remarkably versatile enzyme
AU - Michell, Robert
PY - 2002/4/1
Y1 - 2002/4/1
N2 - Ins(3,4,5,6)P(4) is an inhibitor of Ca(2+)-activated Cl(-) channels, but further understanding has been hindered by ignorance of how it is made in cells. It now transpires that one protein with ATP-dependent kinase and phosphatase activities interconverts Ins(3,4,5,6)P(4) and Ins(1,3,4,5,6)P(5), as well as several other inositol polyphosphates.
AB - Ins(3,4,5,6)P(4) is an inhibitor of Ca(2+)-activated Cl(-) channels, but further understanding has been hindered by ignorance of how it is made in cells. It now transpires that one protein with ATP-dependent kinase and phosphatase activities interconverts Ins(3,4,5,6)P(4) and Ins(1,3,4,5,6)P(5), as well as several other inositol polyphosphates.
UR - http://www.scopus.com/inward/record.url?scp=0037197810&partnerID=8YFLogxK
U2 - 10.1016/S0960-9822(02)00827-8
DO - 10.1016/S0960-9822(02)00827-8
M3 - Article
C2 - 12007430
SN - 1879-0445
VL - 12
SP - R313-5
JO - Current Biology
JF - Current Biology
IS - 9
ER -