Innate receptors for adaptive immunity

Research output: Contribution to journalReview articlepeer-review

Authors

Colleges, School and Institutes

External organisations

  • Centre International de Recherche en Infectiologie
  • Department of Biochemistry

Abstract

Pattern recognition receptors (PRRs) are commonly known as sensor proteins crucial for the early detection of microbial or host-derived stress signals by innate immune cells. Interestingly, some PRRs are also expressed and functional in cells of the adaptive immune system. These receptors provide lymphocytes with innate sensing abilities; for example, B cells express Toll-like receptors, which are important for the humoral response. Strikingly, certain other NOD-like receptors are not only highly expressed in adaptive immune cells, but also exert functions related specifically to adaptive immune system pathways, such as regulating antigen presentation. In this review, we will focus particularly on the current understanding of PRR functions intrinsic to B and T lymphocytes; a developing aspect of PRR biology.

Bibliographic note

Funding Information: We thank F. Martinon, S. Chelbi, and K. Ludigs, UNIL, Lausanne, Switzerland, for critical reading of the manuscript. Studies in the group of GG are funded by the Swiss National Science Foundation ( PP00P3_139094 ) and the European Research Council ( ERC-2012-StG310890 ). MCM is supported by the Institut National de la Santé et de la Recherche Médicale and Université de Lyon I . KM is supported by an Australian National Health and Medical Research Council Overseas Biomedical Training Fellowship (ID 1013515 ).

Details

Original languageEnglish
Pages (from-to)296-302
Number of pages7
JournalCurrent Opinion in Microbiology
Volume16
Issue number3
Publication statusPublished - Jun 2013