Innate defense against fungal pathogens

Research output: Contribution to journalArticlepeer-review

Authors

Colleges, School and Institutes

External organisations

  • University of Aberdeen
  • University of Pittsburgh
  • Department of Astronomy, Case Western Reserve University
  • Louis Stokes Veterans Affairs Medical Centre

Abstract

Human fungal infections have been on the rise in recent years and proved increasingly difficult to treat as a result of the lack of diagnostics, effective antifungal therapies, and vaccines. Most pathogenic fungi do not cause disease unless there is a disturbance in immune homeostasis, which can be caused by modern medical interventions, disease-induced immunosuppression, and naturally occurring human mutations. The innate immune system is well equipped to recognize and destroy pathogenic fungi through specialized cells expressing a broad range of pattern recognition receptors (PRRs). This review will outline the cells and PRRs required for effective antifungal immunity, with a special focus on the major antifungal cytokine IL-17 and recently characterized antifungal inflammasomes.

Details

Original languageEnglish
Article numbera019620
Number of pages20
JournalCold Spring Harbor Perspectives in Medicine
Volume5
Issue number6
Publication statusPublished - 1 Jun 2015