Abstract
Curcumin is a compound derived from the spice, tumeric. It is a potent inhibitor of the SERCA Ca2+ pumps (all isoforms), inhibiting Ca2+-dependent ATPase activity with IC50 values of between 7 and 15 microm. It also inhibits ATP-dependent Ca2+-uptake in a variety of microsomal membranes, although for cerebellar and platelet microsomes, a stimulation in Ca2+ uptake is observed at low curcumin concentrations (
Original language | English |
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Pages (from-to) | 6318-27 |
Number of pages | 10 |
Journal | European Journal of Biochemistry |
Volume | 268 |
Issue number | 23 |
DOIs | |
Publication status | Published - 1 Dec 2001 |
Keywords
- fluorescence
- phosphorylation
- curcumin
- SERCA
- ATP binding