Abstract
Exposure of the frog neuromuscular junction to cationized ferritin (200 micrograms ml-1) results in a reduction in MEPP frequency of approximately 25% within 10 min. This effect is not dependent on extracellular Ca2+, and identical results are obtained in salines buffered with EGTA. It is suggested that cationized ferritin does not inhibit transmitter release via a reduction in the intracellular Ca2+ concentration, but exerts its effect by a direct action on exocytosis. A mode of action is proposed. Unlike Con A, cationized ferritin is unable to suppress the stimulation of spontaneous release caused by high osmolarity.
| Original language | English |
|---|---|
| Pages (from-to) | 246-8 |
| Number of pages | 3 |
| Journal | Naunyn-Schmiedeberg's Archives of Pharmacology |
| Volume | 318 |
| Issue number | 3 |
| Publication status | Published - Feb 1982 |
Keywords
- Animals
- Concanavalin A
- Ferritins
- In Vitro Techniques
- Ligands
- Motor Endplate
- Neuromuscular Junction
- Neurotransmitter Agents
- Osmolar Concentration
- Polymers
- Rana temporaria