Inhibition of spontaneous transmitter release by the membrane ligand cationized ferritin

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Inhibition of spontaneous transmitter release by the membrane ligand cationized ferritin. / Publicover, S J.

In: Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 318, No. 3, 02.1982, p. 246-8.

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@article{35dad31ea797496fa66c5f6edf027577,
title = "Inhibition of spontaneous transmitter release by the membrane ligand cationized ferritin",
abstract = "Exposure of the frog neuromuscular junction to cationized ferritin (200 micrograms ml-1) results in a reduction in MEPP frequency of approximately 25% within 10 min. This effect is not dependent on extracellular Ca2+, and identical results are obtained in salines buffered with EGTA. It is suggested that cationized ferritin does not inhibit transmitter release via a reduction in the intracellular Ca2+ concentration, but exerts its effect by a direct action on exocytosis. A mode of action is proposed. Unlike Con A, cationized ferritin is unable to suppress the stimulation of spontaneous release caused by high osmolarity.",
keywords = "Animals, Concanavalin A, Ferritins, In Vitro Techniques, Ligands, Motor Endplate, Neuromuscular Junction, Neurotransmitter Agents, Osmolar Concentration, Polymers, Rana temporaria",
author = "Publicover, {S J}",
year = "1982",
month = feb,
language = "English",
volume = "318",
pages = "246--8",
journal = "Naunyn-Schmiedeberg's Archives of Pharmacology",
issn = "0028-1298",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Inhibition of spontaneous transmitter release by the membrane ligand cationized ferritin

AU - Publicover, S J

PY - 1982/2

Y1 - 1982/2

N2 - Exposure of the frog neuromuscular junction to cationized ferritin (200 micrograms ml-1) results in a reduction in MEPP frequency of approximately 25% within 10 min. This effect is not dependent on extracellular Ca2+, and identical results are obtained in salines buffered with EGTA. It is suggested that cationized ferritin does not inhibit transmitter release via a reduction in the intracellular Ca2+ concentration, but exerts its effect by a direct action on exocytosis. A mode of action is proposed. Unlike Con A, cationized ferritin is unable to suppress the stimulation of spontaneous release caused by high osmolarity.

AB - Exposure of the frog neuromuscular junction to cationized ferritin (200 micrograms ml-1) results in a reduction in MEPP frequency of approximately 25% within 10 min. This effect is not dependent on extracellular Ca2+, and identical results are obtained in salines buffered with EGTA. It is suggested that cationized ferritin does not inhibit transmitter release via a reduction in the intracellular Ca2+ concentration, but exerts its effect by a direct action on exocytosis. A mode of action is proposed. Unlike Con A, cationized ferritin is unable to suppress the stimulation of spontaneous release caused by high osmolarity.

KW - Animals

KW - Concanavalin A

KW - Ferritins

KW - In Vitro Techniques

KW - Ligands

KW - Motor Endplate

KW - Neuromuscular Junction

KW - Neurotransmitter Agents

KW - Osmolar Concentration

KW - Polymers

KW - Rana temporaria

M3 - Article

C2 - 6121298

VL - 318

SP - 246

EP - 248

JO - Naunyn-Schmiedeberg's Archives of Pharmacology

JF - Naunyn-Schmiedeberg's Archives of Pharmacology

SN - 0028-1298

IS - 3

ER -