Inhibition of quantal transmitter release by the polycationic ligand cationized ferritin

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Colleges, School and Institutes

Abstract

Cationized ferritin (200 micrograms ml-1) causes a reduction in both spontaneous and evoked transmitter release at the frog neuromuscular junction. The reduction in EPP amplitude probably reflects reduced Ca2+ -influx since full recovery can be achieved by elevation of [Ca2+]o. The effect on MEPP frequency is independent of [Ca2+]o and may well reflect a direct effect on exocytosis.

Details

Original languageEnglish
Pages (from-to)629-32
Number of pages4
JournalExperimental Brain Research
Volume59
Issue number3
Publication statusPublished - 1985

Keywords

  • Animals, Calcium, Electrophysiology, Ferritins, Ligands, Microscopy, Electron, Motor Endplate, Nerve Endings, Neural Inhibition, Neuromuscular Junction, Neurotransmitter Agents, Rana temporaria, Time Factors