Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate

Research output: Contribution to journalArticlepeer-review

Standard

Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate. / Larsson, Olof; Barker, Christopher J.; Sjöholm, Åke; Carlqvist, Håkan; Michell, Robert H.; Bertorello, Alejandro; Nilsson, Thomas; Honkanen, Richard E.; Mayr, Georg W.; Zwiller, Jean; Berggren, Per Olof.

In: Science, Vol. 278, No. 5337, 17.10.1997, p. 471-474.

Research output: Contribution to journalArticlepeer-review

Harvard

Larsson, O, Barker, CJ, Sjöholm, Å, Carlqvist, H, Michell, RH, Bertorello, A, Nilsson, T, Honkanen, RE, Mayr, GW, Zwiller, J & Berggren, PO 1997, 'Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate', Science, vol. 278, no. 5337, pp. 471-474. https://doi.org/10.1126/science.278.5337.471

APA

Larsson, O., Barker, C. J., Sjöholm, Å., Carlqvist, H., Michell, R. H., Bertorello, A., Nilsson, T., Honkanen, R. E., Mayr, G. W., Zwiller, J., & Berggren, P. O. (1997). Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate. Science, 278(5337), 471-474. https://doi.org/10.1126/science.278.5337.471

Vancouver

Larsson O, Barker CJ, Sjöholm Å, Carlqvist H, Michell RH, Bertorello A et al. Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate. Science. 1997 Oct 17;278(5337):471-474. https://doi.org/10.1126/science.278.5337.471

Author

Larsson, Olof ; Barker, Christopher J. ; Sjöholm, Åke ; Carlqvist, Håkan ; Michell, Robert H. ; Bertorello, Alejandro ; Nilsson, Thomas ; Honkanen, Richard E. ; Mayr, Georg W. ; Zwiller, Jean ; Berggren, Per Olof. / Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate. In: Science. 1997 ; Vol. 278, No. 5337. pp. 471-474.

Bibtex

@article{03cab15eab9049d0b7f938ffc71a0b61,
title = "Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate",
abstract = "Inositol hexakisphosphate (InsP6), the dominant inositol phosphate in insulin-secreting pancreatic β cells, inhibited the serine-threonine protein phosphatases type 1, type 2A, and type 3 in a concentration-dependent manner. The activity of voltage-gated L-type calcium channels is increased in cells treated with inhibitors of serine-threonine protein phosphatases. Thus, the increased calcium channel activity obtained in the presence of InsP6 might result from the inhibition of phosphatase activity. Glucose elicited a transient increase in InsP6 concentration, which indicates that this inositol polyphosphate may modulate calcium influx over the plasma membrane and serve as a signal in the pancreatic β cell stimulus-secretion coupling.",
author = "Olof Larsson and Barker, {Christopher J.} and {\AA}ke Sj{\"o}holm and H{\aa}kan Carlqvist and Michell, {Robert H.} and Alejandro Bertorello and Thomas Nilsson and Honkanen, {Richard E.} and Mayr, {Georg W.} and Jean Zwiller and Berggren, {Per Olof}",
year = "1997",
month = oct,
day = "17",
doi = "10.1126/science.278.5337.471",
language = "English",
volume = "278",
pages = "471--474",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5337",

}

RIS

TY - JOUR

T1 - Inhibition of phosphatases and increased Ca2+ channel activity by inositol hexakisphosphate

AU - Larsson, Olof

AU - Barker, Christopher J.

AU - Sjöholm, Åke

AU - Carlqvist, Håkan

AU - Michell, Robert H.

AU - Bertorello, Alejandro

AU - Nilsson, Thomas

AU - Honkanen, Richard E.

AU - Mayr, Georg W.

AU - Zwiller, Jean

AU - Berggren, Per Olof

PY - 1997/10/17

Y1 - 1997/10/17

N2 - Inositol hexakisphosphate (InsP6), the dominant inositol phosphate in insulin-secreting pancreatic β cells, inhibited the serine-threonine protein phosphatases type 1, type 2A, and type 3 in a concentration-dependent manner. The activity of voltage-gated L-type calcium channels is increased in cells treated with inhibitors of serine-threonine protein phosphatases. Thus, the increased calcium channel activity obtained in the presence of InsP6 might result from the inhibition of phosphatase activity. Glucose elicited a transient increase in InsP6 concentration, which indicates that this inositol polyphosphate may modulate calcium influx over the plasma membrane and serve as a signal in the pancreatic β cell stimulus-secretion coupling.

AB - Inositol hexakisphosphate (InsP6), the dominant inositol phosphate in insulin-secreting pancreatic β cells, inhibited the serine-threonine protein phosphatases type 1, type 2A, and type 3 in a concentration-dependent manner. The activity of voltage-gated L-type calcium channels is increased in cells treated with inhibitors of serine-threonine protein phosphatases. Thus, the increased calcium channel activity obtained in the presence of InsP6 might result from the inhibition of phosphatase activity. Glucose elicited a transient increase in InsP6 concentration, which indicates that this inositol polyphosphate may modulate calcium influx over the plasma membrane and serve as a signal in the pancreatic β cell stimulus-secretion coupling.

UR - http://www.scopus.com/inward/record.url?scp=0030667979&partnerID=8YFLogxK

U2 - 10.1126/science.278.5337.471

DO - 10.1126/science.278.5337.471

M3 - Article

C2 - 9334307

AN - SCOPUS:0030667979

VL - 278

SP - 471

EP - 474

JO - Science

JF - Science

SN - 0036-8075

IS - 5337

ER -