Abstract
Previous research draws parallels between ecstasy-related and age-related deficits in cognitive functioning. Age-related impairments in working memory have been attributed to a slow down in information processing speed. The present study compared 29 current ecstasy users, 10 previous users and 46 non-users on two tests measuring information processing speed and a computation span task measuring working memory. Results showed that ecstasy users performed worse than non-ecstasy users in the letter comparison task although the overall difference was not significant (p=0.089). Results from the pattern recognition task showed that current ecstasy users produced significantly more errors than the other two groups (p<0.01). When results were combined for both the letter and pattern tasks, once again current ecstasy users produced significantly more errors than non-ecstasy users (p<0.01). Working memory deficits obtained were statistically significant with both ecstasy using groups performing significantly worse than non-users on the computation span measure (p<0.01). Moreover, ANCOVA with measures of processing speed as covariates failed to eliminate the group difference in computation span (p<0.01). Therefore, it is likely the mechanism responsible for impairments in the computation span measure is not the same as that in elderly adults where processing speed generally removes most of the age-related variance. Also of relevance is the fact that the ecstasy users reported here had used a range of other drugs making it difficult to unambiguously attribute the results obtained to ecstasy use.
Original language | English |
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Pages (from-to) | 81-8 |
Number of pages | 8 |
Journal | Human Psychopharmacology: Clinical and Experimental |
Volume | 22 |
Issue number | 2 |
DOIs | |
Publication status | Published - Mar 2007 |
Keywords
- Adult
- Amphetamine/administration & dosage
- Cannabis/chemistry
- Cocaine/administration & dosage
- Ethanol/administration & dosage
- Humans
- Memory/drug effects
- Mental Processes/drug effects
- Multivariate Analysis
- N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage
- Pattern Recognition, Visual/drug effects
- Psychomotor Performance/drug effects
- Reproducibility of Results
- Self Administration
- Substance-Related Disorders/physiopathology
- Surveys and Questionnaires
- Time Factors