Influences on the use of antidepressants in primary care: All England general practice-level analysis of demographic, practice-level and prescriber factors

Research output: Contribution to journalArticlepeer-review

Standard

Influences on the use of antidepressants in primary care : All England general practice-level analysis of demographic, practice-level and prescriber factors. / Heald, Adrian H.; Stedman, Mike; Davies, Mark; Farman, Sanam; Upthegrove, Rachel; Taylor, David; Gadsby, Roger.

In: Human Psychopharmacology, 01.05.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Bibtex

@article{04dc1c8977a54f1a99074a75983cd585,
title = "Influences on the use of antidepressants in primary care: All England general practice-level analysis of demographic, practice-level and prescriber factors",
abstract = "Introduction: General practice (GP) antidepressants (ADs) prescribing in England has almost doubled in the past decade: how does location, GP characteristics, and prescribing selection influence antidepressant prescribing rate (ADPR) and growth. Methods: Stepwise multivariate regression analysis was applied to national public relevant data for each general practice to establish associations between these factors and ADPR. The regression coefficient was applied to the actual change in the number of different ADs and costs/dose to extrapolate the impact of these on growth. Results: In 2017–2018, 2.1 billion doses of antidepressant were prescribed into a population of 52 million people in 6,146 larger practices. In the model, location demographics accounted for 62% of the variation in ADPR: including practice size and health raised this to 71%, and local prescribing behaviour to 80%. Practices using more different drugs and lower-cost/dose had higher ADPR. Extrapolation showed that 40% of growth in ADPR could be attributed to the historic changes in these factors. Conclusions: While practice location factors do impact on AD prescription rates, local long-term physical health condition prevalence and prescribing behaviours are almost as important. We hope that our findings can provide insights that are helpful to local clinical behaviour and medicines management.",
keywords = "antidepressant, cost, prescribing, primary care",
author = "Heald, {Adrian H.} and Mike Stedman and Mark Davies and Sanam Farman and Rachel Upthegrove and David Taylor and Roger Gadsby",
year = "2020",
month = may,
day = "1",
doi = "10.1002/hup.2741",
language = "English",
journal = "Human Psychopharmacology: Clinical and Experimental ",
issn = "0885-6222",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - Influences on the use of antidepressants in primary care

T2 - All England general practice-level analysis of demographic, practice-level and prescriber factors

AU - Heald, Adrian H.

AU - Stedman, Mike

AU - Davies, Mark

AU - Farman, Sanam

AU - Upthegrove, Rachel

AU - Taylor, David

AU - Gadsby, Roger

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Introduction: General practice (GP) antidepressants (ADs) prescribing in England has almost doubled in the past decade: how does location, GP characteristics, and prescribing selection influence antidepressant prescribing rate (ADPR) and growth. Methods: Stepwise multivariate regression analysis was applied to national public relevant data for each general practice to establish associations between these factors and ADPR. The regression coefficient was applied to the actual change in the number of different ADs and costs/dose to extrapolate the impact of these on growth. Results: In 2017–2018, 2.1 billion doses of antidepressant were prescribed into a population of 52 million people in 6,146 larger practices. In the model, location demographics accounted for 62% of the variation in ADPR: including practice size and health raised this to 71%, and local prescribing behaviour to 80%. Practices using more different drugs and lower-cost/dose had higher ADPR. Extrapolation showed that 40% of growth in ADPR could be attributed to the historic changes in these factors. Conclusions: While practice location factors do impact on AD prescription rates, local long-term physical health condition prevalence and prescribing behaviours are almost as important. We hope that our findings can provide insights that are helpful to local clinical behaviour and medicines management.

AB - Introduction: General practice (GP) antidepressants (ADs) prescribing in England has almost doubled in the past decade: how does location, GP characteristics, and prescribing selection influence antidepressant prescribing rate (ADPR) and growth. Methods: Stepwise multivariate regression analysis was applied to national public relevant data for each general practice to establish associations between these factors and ADPR. The regression coefficient was applied to the actual change in the number of different ADs and costs/dose to extrapolate the impact of these on growth. Results: In 2017–2018, 2.1 billion doses of antidepressant were prescribed into a population of 52 million people in 6,146 larger practices. In the model, location demographics accounted for 62% of the variation in ADPR: including practice size and health raised this to 71%, and local prescribing behaviour to 80%. Practices using more different drugs and lower-cost/dose had higher ADPR. Extrapolation showed that 40% of growth in ADPR could be attributed to the historic changes in these factors. Conclusions: While practice location factors do impact on AD prescription rates, local long-term physical health condition prevalence and prescribing behaviours are almost as important. We hope that our findings can provide insights that are helpful to local clinical behaviour and medicines management.

KW - antidepressant

KW - cost

KW - prescribing

KW - primary care

UR - http://www.scopus.com/inward/record.url?scp=85085876766&partnerID=8YFLogxK

U2 - 10.1002/hup.2741

DO - 10.1002/hup.2741

M3 - Article

AN - SCOPUS:85085876766

JO - Human Psychopharmacology: Clinical and Experimental

JF - Human Psychopharmacology: Clinical and Experimental

SN - 0885-6222

ER -