Influences of age, gender, smoking and family history on autoimmune thyroid disease phentotype

Research output: Contribution to journalArticle

Standard

Influences of age, gender, smoking and family history on autoimmune thyroid disease phentotype. / Manji, Nilusha; Carr-Smith, Jacqueline; Boelaert, Kristien; Allahabadia, A; Armitage, M; Chatterjee, VK; Lazarus, JH; Pearce, SHS; Vaidya, B; Gough, Stephen; Franklyn, Jayne.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 91, No. 12, 26.09.2006, p. 4873-4880.

Research output: Contribution to journalArticle

Harvard

Manji, N, Carr-Smith, J, Boelaert, K, Allahabadia, A, Armitage, M, Chatterjee, VK, Lazarus, JH, Pearce, SHS, Vaidya, B, Gough, S & Franklyn, J 2006, 'Influences of age, gender, smoking and family history on autoimmune thyroid disease phentotype', Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 12, pp. 4873-4880. https://doi.org/10.1210/jc.2006-1402

APA

Vancouver

Author

Manji, Nilusha ; Carr-Smith, Jacqueline ; Boelaert, Kristien ; Allahabadia, A ; Armitage, M ; Chatterjee, VK ; Lazarus, JH ; Pearce, SHS ; Vaidya, B ; Gough, Stephen ; Franklyn, Jayne. / Influences of age, gender, smoking and family history on autoimmune thyroid disease phentotype. In: Journal of Clinical Endocrinology and Metabolism. 2006 ; Vol. 91, No. 12. pp. 4873-4880.

Bibtex

@article{ecf827c86aa44602a0860cc59dd3d72e,
title = "Influences of age, gender, smoking and family history on autoimmune thyroid disease phentotype",
abstract = "Context: Both genetic and environmental factors contribute to susceptibility to Graves' disease (GD) and Hashimoto's thyroiditis (HT), as well as disease manifestations. Objective: The objective of the study was to define how endogenous/ environmental factors contribute to variation in phenotype. Design/Setting: This was a multicenter cohort study. Patients/Outcome Measures: We prospectively collected clinical/biochemical data as part of the protocol for a United Kingdom DNA collection for GD and HT. We investigated, in 2805 Caucasian subjects, whether age at diagnosis, gender, family history (FH), smoking history, and presence of goiter influenced disease manifestations. Results: For 2405 subjects with GD, the presence of goiter was independently associated with disease severity (serum free T-4 at diagnosis) (P <0.001). Free T-4 (P <0.05) and current smoking (P <0.001) were both independent predictors of the presence of ophthalmopathy. Approximately half of those with GD (47.4% of females, 40.0% of males) and HT (n = 400) (56.4% of females, 51.7% of males) reported a FH of thyroid dysfunction. In GD, a FH of hyperthyroidism in any relative was more frequent than hypothyroidism (30.1 vs. 24.4% in affected females, P <0.001). In HT, a FH of hypothyroidism was more common than hyperthyroidism (42.1 vs. 22.8% in affected females, P <0.001). For GD (P <0.001) and HT (P <0.05), a FH was more common in maternal than paternal relatives. The reporting of a parent with thyroid dysfunction (hyper or hypo) was associated with lower median age at diagnosis of both GD (mother with hyperthyroidism, P <0.001) and HT (father with hypothyroidism, P <0.05). In GD and HT, there was an inverse relationship between the number of relatives with thyroid dysfunction and age at diagnosis (P <0.01). Conclusions: Marked associations among age at diagnosis, disease severity, goiter, ophthalmopathy, smoking, and FH provide evidence for interactions between genetic and environmental/endogenous factors; understanding these may allow preventive measures or better tailoring of therapies.",
author = "Nilusha Manji and Jacqueline Carr-Smith and Kristien Boelaert and A Allahabadia and M Armitage and VK Chatterjee and JH Lazarus and SHS Pearce and B Vaidya and Stephen Gough and Jayne Franklyn",
year = "2006",
month = sep,
day = "26",
doi = "10.1210/jc.2006-1402",
language = "English",
volume = "91",
pages = "4873--4880",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Endocrine Society",
number = "12",

}

RIS

TY - JOUR

T1 - Influences of age, gender, smoking and family history on autoimmune thyroid disease phentotype

AU - Manji, Nilusha

AU - Carr-Smith, Jacqueline

AU - Boelaert, Kristien

AU - Allahabadia, A

AU - Armitage, M

AU - Chatterjee, VK

AU - Lazarus, JH

AU - Pearce, SHS

AU - Vaidya, B

AU - Gough, Stephen

AU - Franklyn, Jayne

PY - 2006/9/26

Y1 - 2006/9/26

N2 - Context: Both genetic and environmental factors contribute to susceptibility to Graves' disease (GD) and Hashimoto's thyroiditis (HT), as well as disease manifestations. Objective: The objective of the study was to define how endogenous/ environmental factors contribute to variation in phenotype. Design/Setting: This was a multicenter cohort study. Patients/Outcome Measures: We prospectively collected clinical/biochemical data as part of the protocol for a United Kingdom DNA collection for GD and HT. We investigated, in 2805 Caucasian subjects, whether age at diagnosis, gender, family history (FH), smoking history, and presence of goiter influenced disease manifestations. Results: For 2405 subjects with GD, the presence of goiter was independently associated with disease severity (serum free T-4 at diagnosis) (P <0.001). Free T-4 (P <0.05) and current smoking (P <0.001) were both independent predictors of the presence of ophthalmopathy. Approximately half of those with GD (47.4% of females, 40.0% of males) and HT (n = 400) (56.4% of females, 51.7% of males) reported a FH of thyroid dysfunction. In GD, a FH of hyperthyroidism in any relative was more frequent than hypothyroidism (30.1 vs. 24.4% in affected females, P <0.001). In HT, a FH of hypothyroidism was more common than hyperthyroidism (42.1 vs. 22.8% in affected females, P <0.001). For GD (P <0.001) and HT (P <0.05), a FH was more common in maternal than paternal relatives. The reporting of a parent with thyroid dysfunction (hyper or hypo) was associated with lower median age at diagnosis of both GD (mother with hyperthyroidism, P <0.001) and HT (father with hypothyroidism, P <0.05). In GD and HT, there was an inverse relationship between the number of relatives with thyroid dysfunction and age at diagnosis (P <0.01). Conclusions: Marked associations among age at diagnosis, disease severity, goiter, ophthalmopathy, smoking, and FH provide evidence for interactions between genetic and environmental/endogenous factors; understanding these may allow preventive measures or better tailoring of therapies.

AB - Context: Both genetic and environmental factors contribute to susceptibility to Graves' disease (GD) and Hashimoto's thyroiditis (HT), as well as disease manifestations. Objective: The objective of the study was to define how endogenous/ environmental factors contribute to variation in phenotype. Design/Setting: This was a multicenter cohort study. Patients/Outcome Measures: We prospectively collected clinical/biochemical data as part of the protocol for a United Kingdom DNA collection for GD and HT. We investigated, in 2805 Caucasian subjects, whether age at diagnosis, gender, family history (FH), smoking history, and presence of goiter influenced disease manifestations. Results: For 2405 subjects with GD, the presence of goiter was independently associated with disease severity (serum free T-4 at diagnosis) (P <0.001). Free T-4 (P <0.05) and current smoking (P <0.001) were both independent predictors of the presence of ophthalmopathy. Approximately half of those with GD (47.4% of females, 40.0% of males) and HT (n = 400) (56.4% of females, 51.7% of males) reported a FH of thyroid dysfunction. In GD, a FH of hyperthyroidism in any relative was more frequent than hypothyroidism (30.1 vs. 24.4% in affected females, P <0.001). In HT, a FH of hypothyroidism was more common than hyperthyroidism (42.1 vs. 22.8% in affected females, P <0.001). For GD (P <0.001) and HT (P <0.05), a FH was more common in maternal than paternal relatives. The reporting of a parent with thyroid dysfunction (hyper or hypo) was associated with lower median age at diagnosis of both GD (mother with hyperthyroidism, P <0.001) and HT (father with hypothyroidism, P <0.05). In GD and HT, there was an inverse relationship between the number of relatives with thyroid dysfunction and age at diagnosis (P <0.01). Conclusions: Marked associations among age at diagnosis, disease severity, goiter, ophthalmopathy, smoking, and FH provide evidence for interactions between genetic and environmental/endogenous factors; understanding these may allow preventive measures or better tailoring of therapies.

UR - http://www.scopus.com/inward/record.url?scp=33845496763&partnerID=8YFLogxK

U2 - 10.1210/jc.2006-1402

DO - 10.1210/jc.2006-1402

M3 - Article

C2 - 16968788

VL - 91

SP - 4873

EP - 4880

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 12

ER -