Inflammatory bowel disease cause-specific mortality: a primer for clinicians

Research output: Contribution to journalReview articlepeer-review

Standard

Inflammatory bowel disease cause-specific mortality : a primer for clinicians. / Kassam, Zain; Belga, Sara; Roifman, Idan; Hirota, Simon; Jijon, Humberto; Kaplan, Gilaad G.; Ghosh, Subrata; Beck, Paul L.

In: Inflammatory Bowel Diseases, Vol. 20, No. 12, 02.09.2014, p. 2483-2492.

Research output: Contribution to journalReview articlepeer-review

Harvard

Kassam, Z, Belga, S, Roifman, I, Hirota, S, Jijon, H, Kaplan, GG, Ghosh, S & Beck, PL 2014, 'Inflammatory bowel disease cause-specific mortality: a primer for clinicians', Inflammatory Bowel Diseases, vol. 20, no. 12, pp. 2483-2492. https://doi.org/10.1097/MIB.0000000000000173

APA

Kassam, Z., Belga, S., Roifman, I., Hirota, S., Jijon, H., Kaplan, G. G., Ghosh, S., & Beck, P. L. (2014). Inflammatory bowel disease cause-specific mortality: a primer for clinicians. Inflammatory Bowel Diseases, 20(12), 2483-2492. https://doi.org/10.1097/MIB.0000000000000173

Vancouver

Kassam Z, Belga S, Roifman I, Hirota S, Jijon H, Kaplan GG et al. Inflammatory bowel disease cause-specific mortality: a primer for clinicians. Inflammatory Bowel Diseases. 2014 Sep 2;20(12):2483-2492. https://doi.org/10.1097/MIB.0000000000000173

Author

Kassam, Zain ; Belga, Sara ; Roifman, Idan ; Hirota, Simon ; Jijon, Humberto ; Kaplan, Gilaad G. ; Ghosh, Subrata ; Beck, Paul L. / Inflammatory bowel disease cause-specific mortality : a primer for clinicians. In: Inflammatory Bowel Diseases. 2014 ; Vol. 20, No. 12. pp. 2483-2492.

Bibtex

@article{24ff12b6e8064aa6b7274823e7d90293,
title = "Inflammatory bowel disease cause-specific mortality: a primer for clinicians",
abstract = "BACKGROUND: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC) is perceived to harbor significant morbidity but limited excess mortality, thought to be driven by colon cancer, compared with the general population. Recent studies suggest mortality rates seem higher than previously understood, and there are emerging threats to mortality. Clinicians must be up to date and able to clearly convey the causes of mortality to arm individual patients with information to meaningfully participate in decisions regarding IBD treatment and maintenance of health.METHODS: A MEDLINE search was conducted to capture all relevant articles. Keyword search included: {"}inflammatory bowel disease,{"} {"}Crohn's disease,{"} {"}ulcerative colitis,{"} and {"}mortality.{"}RESULTS: CD and UC have slightly different causes of mortality; however, malignancy and colorectal cancer-associated mortality remains controversial in IBD. CD mortality seems to be driven by gastrointestinal disease, infection, and respiratory diseases. UC mortality was primarily attributable to gastrointestinal disease and infection. Clostridium difficile infection is an emerging cause of mortality in IBD. UC and CD patients have a marked increase in risk of thromboembolic disease. With advances in medical and surgical interventions, the exploration of treatment-associated mortality must continue to be evaluated.CONCLUSIONS: Clinicians should be aware that conventional causes of death such as malignancy do not seem to be as significant a burden as originally perceived. However, emerging threats such as infection including C. difficile are noteworthy. Although CD and UC share similar causes of death, there seems to be some differences in cause-specific mortality.",
keywords = "cause-specific mortality, inflammatory bowel disease, Crohn's disease, ulcerative colitis, mortality",
author = "Zain Kassam and Sara Belga and Idan Roifman and Simon Hirota and Humberto Jijon and Kaplan, {Gilaad G.} and Subrata Ghosh and Beck, {Paul L.}",
year = "2014",
month = sep,
day = "2",
doi = "10.1097/MIB.0000000000000173",
language = "English",
volume = "20",
pages = "2483--2492",
journal = "Inflammatory Bowel Diseases",
issn = "1078-0998",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

RIS

TY - JOUR

T1 - Inflammatory bowel disease cause-specific mortality

T2 - a primer for clinicians

AU - Kassam, Zain

AU - Belga, Sara

AU - Roifman, Idan

AU - Hirota, Simon

AU - Jijon, Humberto

AU - Kaplan, Gilaad G.

AU - Ghosh, Subrata

AU - Beck, Paul L.

PY - 2014/9/2

Y1 - 2014/9/2

N2 - BACKGROUND: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC) is perceived to harbor significant morbidity but limited excess mortality, thought to be driven by colon cancer, compared with the general population. Recent studies suggest mortality rates seem higher than previously understood, and there are emerging threats to mortality. Clinicians must be up to date and able to clearly convey the causes of mortality to arm individual patients with information to meaningfully participate in decisions regarding IBD treatment and maintenance of health.METHODS: A MEDLINE search was conducted to capture all relevant articles. Keyword search included: "inflammatory bowel disease," "Crohn's disease," "ulcerative colitis," and "mortality."RESULTS: CD and UC have slightly different causes of mortality; however, malignancy and colorectal cancer-associated mortality remains controversial in IBD. CD mortality seems to be driven by gastrointestinal disease, infection, and respiratory diseases. UC mortality was primarily attributable to gastrointestinal disease and infection. Clostridium difficile infection is an emerging cause of mortality in IBD. UC and CD patients have a marked increase in risk of thromboembolic disease. With advances in medical and surgical interventions, the exploration of treatment-associated mortality must continue to be evaluated.CONCLUSIONS: Clinicians should be aware that conventional causes of death such as malignancy do not seem to be as significant a burden as originally perceived. However, emerging threats such as infection including C. difficile are noteworthy. Although CD and UC share similar causes of death, there seems to be some differences in cause-specific mortality.

AB - BACKGROUND: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC) is perceived to harbor significant morbidity but limited excess mortality, thought to be driven by colon cancer, compared with the general population. Recent studies suggest mortality rates seem higher than previously understood, and there are emerging threats to mortality. Clinicians must be up to date and able to clearly convey the causes of mortality to arm individual patients with information to meaningfully participate in decisions regarding IBD treatment and maintenance of health.METHODS: A MEDLINE search was conducted to capture all relevant articles. Keyword search included: "inflammatory bowel disease," "Crohn's disease," "ulcerative colitis," and "mortality."RESULTS: CD and UC have slightly different causes of mortality; however, malignancy and colorectal cancer-associated mortality remains controversial in IBD. CD mortality seems to be driven by gastrointestinal disease, infection, and respiratory diseases. UC mortality was primarily attributable to gastrointestinal disease and infection. Clostridium difficile infection is an emerging cause of mortality in IBD. UC and CD patients have a marked increase in risk of thromboembolic disease. With advances in medical and surgical interventions, the exploration of treatment-associated mortality must continue to be evaluated.CONCLUSIONS: Clinicians should be aware that conventional causes of death such as malignancy do not seem to be as significant a burden as originally perceived. However, emerging threats such as infection including C. difficile are noteworthy. Although CD and UC share similar causes of death, there seems to be some differences in cause-specific mortality.

KW - cause-specific mortality

KW - inflammatory bowel disease

KW - Crohn's disease

KW - ulcerative colitis

KW - mortality

U2 - 10.1097/MIB.0000000000000173

DO - 10.1097/MIB.0000000000000173

M3 - Review article

C2 - 25185685

VL - 20

SP - 2483

EP - 2492

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

IS - 12

ER -