Inflammation-a Critical Appreciation of the Role of Myeloid Cells

Research output: Contribution to journalReview articlepeer-review

Authors

Colleges, School and Institutes

External organisations

  • University of Oxford
  • Departments of Medicine (Cardiology) and Cell Biology, New York University School of Medicine, New York, NY 10016.

Abstract

What is inflammation's big idea? In this brief overview of the role of myeloid cells in inflammation, we will critically discuss what drives the initiation, amplification, and resolution of inflammation in different anatomical sites in response to different pathological stimuli. It can be argued that we have a good understanding of the basic principles that underlie myeloid cell activation and the mobilization of innate immune cells to sites of injury and infection in acute inflammation. The challenge now for inflammation biologists is to understand how resolution of this normal physiological response goes wrong in hyperacute and chronic inflammation. A better understanding of how inflammation is regulated will allow us to develop new anti-inflammatory drugs that will reduce the burden of inflammatory disease without compromising the patient's immune defenses against infectious disease. Ideally such drugs should encourage a return to homeostasis and enhance tissue repair processes.

Details

Original languageEnglish
JournalMicrobiology spectrum
Volume4
Issue number5
Publication statusPublished - 1 Oct 2016

Keywords

  • Animals, Humans, Immunity, Innate, Inflammation, Myeloid Cells, Signal Transduction, Journal Article, Review

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