Inflammation, endothelial dysfunction, and platelet activation in patients with chronic kidney disease: the chronic renal impairment in Birmingham (CRIB) study1

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Inflammation, endothelial dysfunction, and platelet activation in patients with chronic kidney disease: the chronic renal impairment in Birmingham (CRIB) study1. / Landray, M; Wheeler, D; Lip, Gregory; Newman, D; Blann, Andrew; McGlynn, Fiona; [No Value], [No Value]; Townend, Jonathan; Baigent, C.

In: American Journal of Kidney Diseases, Vol. 43, No. 2, 01.02.2004, p. 244-253.

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@article{087a7c4dbec24130997d089c962215e9,
title = "Inflammation, endothelial dysfunction, and platelet activation in patients with chronic kidney disease: the chronic renal impairment in Birmingham (CRIB) study1",
abstract = "BACKGROUND: Studies in the general population suggest that low-grade inflammation, endothelial dysfunction, and platelet activation are associated with an increased risk of cardiovascular events. METHODS: Markers of inflammation, endothelial dysfunction, and platelet activation were measured in 334 patients with chronic kidney disease (serum creatinine >1.47 mg/dL [>130 micromol/L] at screening) and compared with 2 age- and sex-matched control groups, 1 comprising 92 patients with coronary artery disease and the other comprising 96 apparently healthy individuals with no history of cardiovascular or kidney disease. RESULTS: There was evidence of low-grade inflammation in the chronic renal impairment group compared with healthy controls, with higher concentrations of C-reactive protein (3.70 versus 2.18 mg/L, P <0.01) and fibrinogen (3.48 versus 2.67 g/L, P <0.001) and lower serum albumin concentration (41.8 versus 44.0 g/dL [418 versus 440 g/L], P <0.001). More severe renal impairment was associated with a trend towards higher fibrinogen and lower albumin concentrations (both P <0.001), although there was no association with higher C-reactive protein level. As compared to healthy controls, plasma von Willebrand factor (142 versus 108 IU/dL, P <0.001) and soluble P-selectin concentrations (57.0 versus 43.3 ng/mL, P <0.001) were also higher in the chronic renal impairment group. More severe renal impairment was associated with a trend towards higher levels of von Willebrand factor (P <0.001) and of soluble P selectin (P <0.05). CONCLUSION: This cross-sectional analysis demonstrates that chronic kidney disease is associated with low-grade inflammation, endothelial dysfunction, and platelet activation, even among patients with moderate renal impairment.",
keywords = "platelet activation, inflammation, endothelial dysfunction, chronic kidney disease (CKD), cardiovascular disease (CVD)",
author = "M Landray and D Wheeler and Gregory Lip and D Newman and Andrew Blann and Fiona McGlynn and {[No Value]}, {[No Value]} and Jonathan Townend and C Baigent",
year = "2004",
month = feb,
day = "1",
doi = "10.1053/j.ajkd.2003.10.037",
language = "English",
volume = "43",
pages = "244--253",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Inflammation, endothelial dysfunction, and platelet activation in patients with chronic kidney disease: the chronic renal impairment in Birmingham (CRIB) study1

AU - Landray, M

AU - Wheeler, D

AU - Lip, Gregory

AU - Newman, D

AU - Blann, Andrew

AU - McGlynn, Fiona

AU - [No Value], [No Value]

AU - Townend, Jonathan

AU - Baigent, C

PY - 2004/2/1

Y1 - 2004/2/1

N2 - BACKGROUND: Studies in the general population suggest that low-grade inflammation, endothelial dysfunction, and platelet activation are associated with an increased risk of cardiovascular events. METHODS: Markers of inflammation, endothelial dysfunction, and platelet activation were measured in 334 patients with chronic kidney disease (serum creatinine >1.47 mg/dL [>130 micromol/L] at screening) and compared with 2 age- and sex-matched control groups, 1 comprising 92 patients with coronary artery disease and the other comprising 96 apparently healthy individuals with no history of cardiovascular or kidney disease. RESULTS: There was evidence of low-grade inflammation in the chronic renal impairment group compared with healthy controls, with higher concentrations of C-reactive protein (3.70 versus 2.18 mg/L, P <0.01) and fibrinogen (3.48 versus 2.67 g/L, P <0.001) and lower serum albumin concentration (41.8 versus 44.0 g/dL [418 versus 440 g/L], P <0.001). More severe renal impairment was associated with a trend towards higher fibrinogen and lower albumin concentrations (both P <0.001), although there was no association with higher C-reactive protein level. As compared to healthy controls, plasma von Willebrand factor (142 versus 108 IU/dL, P <0.001) and soluble P-selectin concentrations (57.0 versus 43.3 ng/mL, P <0.001) were also higher in the chronic renal impairment group. More severe renal impairment was associated with a trend towards higher levels of von Willebrand factor (P <0.001) and of soluble P selectin (P <0.05). CONCLUSION: This cross-sectional analysis demonstrates that chronic kidney disease is associated with low-grade inflammation, endothelial dysfunction, and platelet activation, even among patients with moderate renal impairment.

AB - BACKGROUND: Studies in the general population suggest that low-grade inflammation, endothelial dysfunction, and platelet activation are associated with an increased risk of cardiovascular events. METHODS: Markers of inflammation, endothelial dysfunction, and platelet activation were measured in 334 patients with chronic kidney disease (serum creatinine >1.47 mg/dL [>130 micromol/L] at screening) and compared with 2 age- and sex-matched control groups, 1 comprising 92 patients with coronary artery disease and the other comprising 96 apparently healthy individuals with no history of cardiovascular or kidney disease. RESULTS: There was evidence of low-grade inflammation in the chronic renal impairment group compared with healthy controls, with higher concentrations of C-reactive protein (3.70 versus 2.18 mg/L, P <0.01) and fibrinogen (3.48 versus 2.67 g/L, P <0.001) and lower serum albumin concentration (41.8 versus 44.0 g/dL [418 versus 440 g/L], P <0.001). More severe renal impairment was associated with a trend towards higher fibrinogen and lower albumin concentrations (both P <0.001), although there was no association with higher C-reactive protein level. As compared to healthy controls, plasma von Willebrand factor (142 versus 108 IU/dL, P <0.001) and soluble P-selectin concentrations (57.0 versus 43.3 ng/mL, P <0.001) were also higher in the chronic renal impairment group. More severe renal impairment was associated with a trend towards higher levels of von Willebrand factor (P <0.001) and of soluble P selectin (P <0.05). CONCLUSION: This cross-sectional analysis demonstrates that chronic kidney disease is associated with low-grade inflammation, endothelial dysfunction, and platelet activation, even among patients with moderate renal impairment.

KW - platelet activation

KW - inflammation

KW - endothelial dysfunction

KW - chronic kidney disease (CKD)

KW - cardiovascular disease (CVD)

U2 - 10.1053/j.ajkd.2003.10.037

DO - 10.1053/j.ajkd.2003.10.037

M3 - Article

C2 - 14750089

VL - 43

SP - 244

EP - 253

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 2

ER -