Inflammation, carotid intima-media thickness and atherosclerosis in rheumatoid arthritis

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Inflammation, carotid intima-media thickness and atherosclerosis in rheumatoid arthritis. / Veldhuijzen van Zanten, Joachimina; Kitas, George.

In: Arthritis Research & Therapy, Vol. 10, No. 1, 01.01.2008, p. 102-.

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@article{5223bba8333445d6a3433977595aaaaf,
title = "Inflammation, carotid intima-media thickness and atherosclerosis in rheumatoid arthritis",
abstract = "Carotid intima-media thickness (cIMT) reflects early atherosclerosis and predicts cardiovascular events in the general population. An increased cIMT is present in patients with rheumatoid arthritis, compared with control individuals, from the early stages of the disease and is thought to indicate accelerated atherosclerosis, but direct evidence is not available. Whether cIMT is susceptible to rapid and potentially reversible change depending on the intensity of inflammation in states of high-grade systemic inflammation, such as rheumatoid arthritis, remains unknown. If this is the case, an increased cIMT in such disease states may not reflect structural vessel wall damage, and may not be a good predictor of future cardiovascular events in these particular populations. Prospective, long-term, longitudinal studies are needed to address these questions.",
author = "{Veldhuijzen van Zanten}, Joachimina and George Kitas",
year = "2008",
month = jan,
day = "1",
doi = "10.1186/ar2345",
language = "English",
volume = "10",
pages = "102--",
journal = "Arthritis Research & Therapy",
issn = "1478-6354",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Inflammation, carotid intima-media thickness and atherosclerosis in rheumatoid arthritis

AU - Veldhuijzen van Zanten, Joachimina

AU - Kitas, George

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Carotid intima-media thickness (cIMT) reflects early atherosclerosis and predicts cardiovascular events in the general population. An increased cIMT is present in patients with rheumatoid arthritis, compared with control individuals, from the early stages of the disease and is thought to indicate accelerated atherosclerosis, but direct evidence is not available. Whether cIMT is susceptible to rapid and potentially reversible change depending on the intensity of inflammation in states of high-grade systemic inflammation, such as rheumatoid arthritis, remains unknown. If this is the case, an increased cIMT in such disease states may not reflect structural vessel wall damage, and may not be a good predictor of future cardiovascular events in these particular populations. Prospective, long-term, longitudinal studies are needed to address these questions.

AB - Carotid intima-media thickness (cIMT) reflects early atherosclerosis and predicts cardiovascular events in the general population. An increased cIMT is present in patients with rheumatoid arthritis, compared with control individuals, from the early stages of the disease and is thought to indicate accelerated atherosclerosis, but direct evidence is not available. Whether cIMT is susceptible to rapid and potentially reversible change depending on the intensity of inflammation in states of high-grade systemic inflammation, such as rheumatoid arthritis, remains unknown. If this is the case, an increased cIMT in such disease states may not reflect structural vessel wall damage, and may not be a good predictor of future cardiovascular events in these particular populations. Prospective, long-term, longitudinal studies are needed to address these questions.

U2 - 10.1186/ar2345

DO - 10.1186/ar2345

M3 - Article

C2 - 18226183

VL - 10

SP - 102-

JO - Arthritis Research & Therapy

JF - Arthritis Research & Therapy

SN - 1478-6354

IS - 1

ER -