Inflammasomes of the intestinal epithelium

Research output: Contribution to journalReview articlepeer-review

Authors

Colleges, School and Institutes

External organisations

  • Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland. Electronic address: msellin@micro.biol.ethz.ch.
  • University of Oxford
  • Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland. Electronic address: hardt@micro.biol.ethz.ch.

Abstract

While the functional importance of inflammasomes in blood-derived cell types is well established, it remains poorly understood how inflammasomes in nonhematopoietic cells contribute to mucosal immunity. Recent studies have revealed functional roles of inflammasomes - particularly NAIP/NLRC4, NLRP6, and noncanonical caspase-4 (caspase-11) - within epithelial cells of the gut in mucosal immune defense, inflammation, and tumorigenesis. Here, we review and discuss these findings in the broader context of tissue compartment-specific mucosal immunity. We propose several models whereby activities of the intestinal epithelial inflammasomes converge on mechanisms to remove compromised epithelial cells, maintain host-microbiota mutualism, and communicate with immune cells of the underlying lamina propria.

Details

Original languageEnglish
Pages (from-to)442-50
Number of pages9
JournalTrends in Immunology
Volume36
Issue number8
Publication statusPublished - Aug 2015

Keywords

  • Animals, Humans, Immunity, Mucosal, Inflammasomes, Intestinal Mucosa, Journal Article, Research Support, Non-U.S. Gov't, Review