Inflammasomes of the intestinal epithelium
Research output: Contribution to journal › Review article › peer-review
Colleges, School and Institutes
- Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland. Electronic address: firstname.lastname@example.org.
- University of Oxford
- Institute of Microbiology, ETH Zürich, 8093 Zürich, Switzerland. Electronic address: email@example.com.
While the functional importance of inflammasomes in blood-derived cell types is well established, it remains poorly understood how inflammasomes in nonhematopoietic cells contribute to mucosal immunity. Recent studies have revealed functional roles of inflammasomes - particularly NAIP/NLRC4, NLRP6, and noncanonical caspase-4 (caspase-11) - within epithelial cells of the gut in mucosal immune defense, inflammation, and tumorigenesis. Here, we review and discuss these findings in the broader context of tissue compartment-specific mucosal immunity. We propose several models whereby activities of the intestinal epithelial inflammasomes converge on mechanisms to remove compromised epithelial cells, maintain host-microbiota mutualism, and communicate with immune cells of the underlying lamina propria.
|Number of pages||9|
|Journal||Trends in Immunology|
|Publication status||Published - Aug 2015|
- Animals, Humans, Immunity, Mucosal, Inflammasomes, Intestinal Mucosa, Journal Article, Research Support, Non-U.S. Gov't, Review