Abstract
Choline-binding protein A (CbpA) and pneumolysin (Ply) can induce the expression and release of chemokines by human cells, which might modulate specific immune responses. In dendritic cells (DCs), such effects could be important for the size and character of the immunity induced if administered as vaccines. We studied the induction of CCL and CXCL chemokines by CbpA and Ply in DCs and related signaling pathways.
Original language | English |
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Pages (from-to) | 1823-33 |
Number of pages | 11 |
Journal | The Journal of Infectious Diseases |
Volume | 198 |
Issue number | 12 |
DOIs | |
Publication status | Published - 15 Dec 2008 |
Keywords
- Bacterial Proteins
- Cells, Cultured
- Chemokines, CC
- Chemokines, CXC
- Culture Media, Conditioned
- Dendritic Cells
- Gene Expression Regulation
- Humans
- Mitogen-Activated Protein Kinase Kinases
- NF-kappa B
- Signal Transduction
- Streptolysins
- Toll-Like Receptor 4