Induction of CC and CXC chemokines in human antigen-presenting dendritic cells by the pneumococcal proteins pneumolysin and CbpA, and the role played by toll-like receptor 4, NF-kappaB, and mitogen-activated protein kinases

Research output: Contribution to journalArticlepeer-review

Authors

  • Jolanta Bernatoniene
  • Qibo Zhang
  • Semih Dogan
  • James C Paton
  • Adam Finn

Colleges, School and Institutes

Abstract

Choline-binding protein A (CbpA) and pneumolysin (Ply) can induce the expression and release of chemokines by human cells, which might modulate specific immune responses. In dendritic cells (DCs), such effects could be important for the size and character of the immunity induced if administered as vaccines. We studied the induction of CCL and CXCL chemokines by CbpA and Ply in DCs and related signaling pathways.

Details

Original languageEnglish
Pages (from-to)1823-33
Number of pages11
JournalThe Journal of Infectious Diseases
Volume198
Issue number12
Publication statusPublished - 15 Dec 2008

Keywords

  • Bacterial Proteins, Cells, Cultured, Chemokines, CC, Chemokines, CXC, Culture Media, Conditioned, Dendritic Cells, Gene Expression Regulation, Humans, Mitogen-Activated Protein Kinase Kinases, NF-kappa B, Signal Transduction, Streptolysins, Toll-Like Receptor 4