Inducible ablation of CD11c+ cells to determine their role in skin wound repair

Research output: Contribution to journalLetterpeer-review

Authors

  • Zhi Li
  • Rebecca Lamb
  • Mark Coles
  • Clare Bennette
  • Carrie Ambler

Colleges, School and Institutes

Abstract

Summary: Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL‐23‐IL‐22 axis that is required for wound healing.

Details

Original languageEnglish
JournalImmunology
Early online date27 Jan 2021
Publication statusE-pub ahead of print - 27 Jan 2021

Keywords

  • CD11c, dendritic cells, Langerhans cells, skin, wound repair