Increased resting hippocampal and basal ganglia perfusion in people at ultra high risk for psychosis: replication in a second cohort

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Increased resting hippocampal and basal ganglia perfusion in people at ultra high risk for psychosis: replication in a second cohort. / Allen, Paul; Azis, Matilda; Modinos, Gemma; Bossong, Matthijs; Bonoldi, Illaria; Samson, Carly; Quinn, Beverly; Kempton, Matthew; Howes, Oliver; Stone, James; Calem, Maria; Perez, Jesus; Broome, Matthew; Grace, Anthony ; Zelaya, Fernando; McGuire, Philip.

In: Schizophrenia bulletin, 27.12.2017.

Research output: Contribution to journalArticlepeer-review

Harvard

Allen, P, Azis, M, Modinos, G, Bossong, M, Bonoldi, I, Samson, C, Quinn, B, Kempton, M, Howes, O, Stone, J, Calem, M, Perez, J, Broome, M, Grace, A, Zelaya, F & McGuire, P 2017, 'Increased resting hippocampal and basal ganglia perfusion in people at ultra high risk for psychosis: replication in a second cohort', Schizophrenia bulletin. https://doi.org/10.1093/schbul/sbx169

APA

Allen, P., Azis, M., Modinos, G., Bossong, M., Bonoldi, I., Samson, C., Quinn, B., Kempton, M., Howes, O., Stone, J., Calem, M., Perez, J., Broome, M., Grace, A., Zelaya, F., & McGuire, P. (2017). Increased resting hippocampal and basal ganglia perfusion in people at ultra high risk for psychosis: replication in a second cohort. Schizophrenia bulletin. https://doi.org/10.1093/schbul/sbx169

Vancouver

Author

Allen, Paul ; Azis, Matilda ; Modinos, Gemma ; Bossong, Matthijs ; Bonoldi, Illaria ; Samson, Carly ; Quinn, Beverly ; Kempton, Matthew ; Howes, Oliver ; Stone, James ; Calem, Maria ; Perez, Jesus ; Broome, Matthew ; Grace, Anthony ; Zelaya, Fernando ; McGuire, Philip. / Increased resting hippocampal and basal ganglia perfusion in people at ultra high risk for psychosis: replication in a second cohort. In: Schizophrenia bulletin. 2017.

Bibtex

@article{38b330340cc5425db0e0df81164e95e1,
title = "Increased resting hippocampal and basal ganglia perfusion in people at ultra high risk for psychosis:: replication in a second cohort",
abstract = "We recently reported that resting hippocampal, basal ganglia and midbrain perfusion is elevated in people at ultra-high risk (UHR) for psychosis. The present study sought to replicate our previous finding in an independent UHR cohort, and examined the relationship between resting perfusion in these regions, psychosis and depression symptoms, and traumatic experiences in childhood. Pseudo-Continuous Arterial Spin Labelling (p-CASL) imaging was used to measure resting cerebral blood flow (rCBF) in 77 UHR for psychosis individuals and 25 healthy volunteers in a case-control design. UHR participants were recruited from clinical early detection services at three sites in the South of England. Symptoms levels were assessed using the Comprehensive Assessment of At Risk Mental States (CAARMS), the Hamilton Depression Scale (HAM-D), and childhood trauma was assessed retrospectively using the Childhood Trauma Questionnaire (CTQ). Right hippocampal and basal ganglia rCBF was significantly increased in UHR subjects compared to controls, partially replicating our previous finding in an independent cohort. In UHR participants, positive symptoms were positively correlated with rCBF in the right pallidum. CTQ scores were positively correlated with rCBF values in the bilateral hippocampus and negatively associated with rCBF in the left prefrontal cortex. Elevated resting hippocampal and basal ganglia activity appears to be a consistent finding in individuals at high risk for psychosis, consistent with data from preclinical models of the disorder. The association with childhood trauma suggests that its influence on the risk of psychosis may be mediated through an effect on hippocampal function.",
keywords = "schizophrenia , ultra high-risk , cerebral blood flow , childhood trauma",
author = "Paul Allen and Matilda Azis and Gemma Modinos and Matthijs Bossong and Illaria Bonoldi and Carly Samson and Beverly Quinn and Matthew Kempton and Oliver Howes and James Stone and Maria Calem and Jesus Perez and Matthew Broome and Anthony Grace and Fernando Zelaya and Philip McGuire",
year = "2017",
month = dec,
day = "27",
doi = "10.1093/schbul/sbx169",
language = "English",
journal = "Schizophrenia bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Increased resting hippocampal and basal ganglia perfusion in people at ultra high risk for psychosis:

T2 - replication in a second cohort

AU - Allen, Paul

AU - Azis, Matilda

AU - Modinos, Gemma

AU - Bossong, Matthijs

AU - Bonoldi, Illaria

AU - Samson, Carly

AU - Quinn, Beverly

AU - Kempton, Matthew

AU - Howes, Oliver

AU - Stone, James

AU - Calem, Maria

AU - Perez, Jesus

AU - Broome, Matthew

AU - Grace, Anthony

AU - Zelaya, Fernando

AU - McGuire, Philip

PY - 2017/12/27

Y1 - 2017/12/27

N2 - We recently reported that resting hippocampal, basal ganglia and midbrain perfusion is elevated in people at ultra-high risk (UHR) for psychosis. The present study sought to replicate our previous finding in an independent UHR cohort, and examined the relationship between resting perfusion in these regions, psychosis and depression symptoms, and traumatic experiences in childhood. Pseudo-Continuous Arterial Spin Labelling (p-CASL) imaging was used to measure resting cerebral blood flow (rCBF) in 77 UHR for psychosis individuals and 25 healthy volunteers in a case-control design. UHR participants were recruited from clinical early detection services at three sites in the South of England. Symptoms levels were assessed using the Comprehensive Assessment of At Risk Mental States (CAARMS), the Hamilton Depression Scale (HAM-D), and childhood trauma was assessed retrospectively using the Childhood Trauma Questionnaire (CTQ). Right hippocampal and basal ganglia rCBF was significantly increased in UHR subjects compared to controls, partially replicating our previous finding in an independent cohort. In UHR participants, positive symptoms were positively correlated with rCBF in the right pallidum. CTQ scores were positively correlated with rCBF values in the bilateral hippocampus and negatively associated with rCBF in the left prefrontal cortex. Elevated resting hippocampal and basal ganglia activity appears to be a consistent finding in individuals at high risk for psychosis, consistent with data from preclinical models of the disorder. The association with childhood trauma suggests that its influence on the risk of psychosis may be mediated through an effect on hippocampal function.

AB - We recently reported that resting hippocampal, basal ganglia and midbrain perfusion is elevated in people at ultra-high risk (UHR) for psychosis. The present study sought to replicate our previous finding in an independent UHR cohort, and examined the relationship between resting perfusion in these regions, psychosis and depression symptoms, and traumatic experiences in childhood. Pseudo-Continuous Arterial Spin Labelling (p-CASL) imaging was used to measure resting cerebral blood flow (rCBF) in 77 UHR for psychosis individuals and 25 healthy volunteers in a case-control design. UHR participants were recruited from clinical early detection services at three sites in the South of England. Symptoms levels were assessed using the Comprehensive Assessment of At Risk Mental States (CAARMS), the Hamilton Depression Scale (HAM-D), and childhood trauma was assessed retrospectively using the Childhood Trauma Questionnaire (CTQ). Right hippocampal and basal ganglia rCBF was significantly increased in UHR subjects compared to controls, partially replicating our previous finding in an independent cohort. In UHR participants, positive symptoms were positively correlated with rCBF in the right pallidum. CTQ scores were positively correlated with rCBF values in the bilateral hippocampus and negatively associated with rCBF in the left prefrontal cortex. Elevated resting hippocampal and basal ganglia activity appears to be a consistent finding in individuals at high risk for psychosis, consistent with data from preclinical models of the disorder. The association with childhood trauma suggests that its influence on the risk of psychosis may be mediated through an effect on hippocampal function.

KW - schizophrenia

KW - ultra high-risk

KW - cerebral blood flow

KW - childhood trauma

U2 - 10.1093/schbul/sbx169

DO - 10.1093/schbul/sbx169

M3 - Article

JO - Schizophrenia bulletin

JF - Schizophrenia bulletin

SN - 0586-7614

ER -