Increased levels of soluble P-selectin correlate with iron overload in sickle cell disease

Research output: Contribution to journalArticle

Authors

  • Andrew Blann
  • SS Marwah
  • AJ Cobley
  • D Bareford

Colleges, School and Institutes

Abstract

Homozygous sickle cell disease (SCD) is characterised by increased soluble P-selectin (sP-selectin), suggesting increased platelet activation, and high non-transferrin-bound iron (NTBI), reflecting iron overload, possibly due to blood transfusion. Hypothesising a relationship between these processes, we measured both markers in 40 SCD patients and 40 age/gender/race-matched controls, finding increased levels of each marker in the patients (both P

Details

Original languageEnglish
Pages (from-to)124-6
Number of pages3
JournalBritish journal of biomedical science
Volume64
Issue number3
Publication statusPublished - 1 Jan 2007