Increased food intake following injection of the benzodiazepine receptor agonist midazolam into the IVth ventricle

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

Despite a prolonged period of research with benzodiazepines, the central site(s) of action for the hyperphagic effects of these compounds remains to be determined. The aim of the present studies was to examine the effect of direct administration of the benzodiazepine receptor agonist midazolam into the IVth ventricle on ingestive behavior in nondeprived rats. In Experiment 1, microinjection of midazolam (3 and 30 micrograms/microliter) into the IVth ventricle was sufficient to increase consumption of a palatable mash. In Experiment 2, the hyperphagic effect was blocked by systemic administration of the selective benzodiazepine receptor antagonist flumazenil (20 mg/kg). The results indicate that a brainstem site of action may be important for the effects of benzodiazepine receptor agonists on ingestive behavior.

Details

Original languageEnglish
Pages (from-to)81-6
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume55
Issue number1
Publication statusPublished - 1996