Incorporation of an ultrasound and model guided permissible region improves quantitative source recovery in bioluminescence tomography

Research output: Contribution to journalArticle

Standard

Incorporation of an ultrasound and model guided permissible region improves quantitative source recovery in bioluminescence tomography. / Jayet, Baptiste ; Morgan, Stephen P.; Dehghani, Hamid.

In: Biomedical Optics Express, Vol. 9, No. 3, 01.03.2018, p. 1360-1374.

Research output: Contribution to journalArticle

Harvard

APA

Vancouver

Author

Bibtex

@article{364d79db8d49418b835e1471196f079e,
title = "Incorporation of an ultrasound and model guided permissible region improves quantitative source recovery in bioluminescence tomography",
abstract = "Bioluminescence imaging has shown great potential for studying and monitoringdisease progression in small animal pre-clinical imaging. However, absolute bioluminescence source recovery through tomographic multi-wavelength measurements is often hindered through the lack of quantitative accuracy and suffers from both poor localisation and quantitative recovery. In this work a method to incorporate a permissible region strategy through not only a priorilocation (permissible region) but also based on a model of light propagation and hence light sensitivity is developed and tested using both simulations and experimental data. Reconstructions on two different numerical models (a simple slab, and the digital version of a heterogeneous mouse) shows an improvement of localisation and recovery of intensity (around 25{\%} for the slab model and around 10{\%} for the digital mouse model). This strategy is also used with experimental data from a phantom gel and which demonstrated an improved recovered tomographic image.",
author = "Baptiste Jayet and Morgan, {Stephen P.} and Hamid Dehghani",
year = "2018",
month = "3",
day = "1",
doi = "10.1364/BOE.9.001360",
language = "English",
volume = "9",
pages = "1360--1374",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "Optical Society of America",
number = "3",

}

RIS

TY - JOUR

T1 - Incorporation of an ultrasound and model guided permissible region improves quantitative source recovery in bioluminescence tomography

AU - Jayet, Baptiste

AU - Morgan, Stephen P.

AU - Dehghani, Hamid

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Bioluminescence imaging has shown great potential for studying and monitoringdisease progression in small animal pre-clinical imaging. However, absolute bioluminescence source recovery through tomographic multi-wavelength measurements is often hindered through the lack of quantitative accuracy and suffers from both poor localisation and quantitative recovery. In this work a method to incorporate a permissible region strategy through not only a priorilocation (permissible region) but also based on a model of light propagation and hence light sensitivity is developed and tested using both simulations and experimental data. Reconstructions on two different numerical models (a simple slab, and the digital version of a heterogeneous mouse) shows an improvement of localisation and recovery of intensity (around 25% for the slab model and around 10% for the digital mouse model). This strategy is also used with experimental data from a phantom gel and which demonstrated an improved recovered tomographic image.

AB - Bioluminescence imaging has shown great potential for studying and monitoringdisease progression in small animal pre-clinical imaging. However, absolute bioluminescence source recovery through tomographic multi-wavelength measurements is often hindered through the lack of quantitative accuracy and suffers from both poor localisation and quantitative recovery. In this work a method to incorporate a permissible region strategy through not only a priorilocation (permissible region) but also based on a model of light propagation and hence light sensitivity is developed and tested using both simulations and experimental data. Reconstructions on two different numerical models (a simple slab, and the digital version of a heterogeneous mouse) shows an improvement of localisation and recovery of intensity (around 25% for the slab model and around 10% for the digital mouse model). This strategy is also used with experimental data from a phantom gel and which demonstrated an improved recovered tomographic image.

U2 - 10.1364/BOE.9.001360

DO - 10.1364/BOE.9.001360

M3 - Article

VL - 9

SP - 1360

EP - 1374

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 3

ER -