In fungal intracellular pathogenesis, form determines fate

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In fungal intracellular pathogenesis, form determines fate. / May, Robin C; Casadevall, Arturo.

In: mBio, Vol. 9, No. 5, e02092-18, 23.10.2018.

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May, Robin C ; Casadevall, Arturo. / In fungal intracellular pathogenesis, form determines fate. In: mBio. 2018 ; Vol. 9, No. 5.

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@article{23323a89502248418f0eb52b755270df,
title = "In fungal intracellular pathogenesis, form determines fate",
abstract = "For pathogenic microbes to survive ingestion by macrophages, they must subvert powerful microbicidal mechanisms within the phagolysosome. After ingestion, Candida albicans undergoes a morphological transition producing hyphae, while the surrounding phagosome exhibits a loss of phagosomal acidity. However, how these two events are related has remained enigmatic. Now Westman et al. (mBio 9:e01226-18, 2018, https://doi.org/10.1128/mBio.01226-18) report that phagosomal neutralization results from disruption of phagosomal membrane integrity by the enlarging hyphae, directly implicating the morphological transition in physical damage that promotes intracellular survival. The C. albicans intracellular strategy shows parallels with another fungal pathogen, Cryptococcus neoformans, where a morphological changed involving capsular enlargement intracellularly is associated with loss of membrane integrity and death of the host cell. These similarities among distantly related pathogenic fungi suggest that morphological transitions that are common in fungi directly affect the outcome of the fungal cell-macrophage interaction. For this class of organisms, form determines fate in the intracellular environment.",
keywords = "Candida, Cryptococcus, fungus, macrophage, phagosome",
author = "May, {Robin C} and Arturo Casadevall",
note = "Copyright {\textcopyright} 2018 May and Casadevall.",
year = "2018",
month = oct,
day = "23",
doi = "10.1128/mBio.02092-18",
language = "English",
volume = "9",
journal = "mBio",
issn = "2150-7511",
publisher = "American Society for Microbiology",
number = "5",

}

RIS

TY - JOUR

T1 - In fungal intracellular pathogenesis, form determines fate

AU - May, Robin C

AU - Casadevall, Arturo

N1 - Copyright © 2018 May and Casadevall.

PY - 2018/10/23

Y1 - 2018/10/23

N2 - For pathogenic microbes to survive ingestion by macrophages, they must subvert powerful microbicidal mechanisms within the phagolysosome. After ingestion, Candida albicans undergoes a morphological transition producing hyphae, while the surrounding phagosome exhibits a loss of phagosomal acidity. However, how these two events are related has remained enigmatic. Now Westman et al. (mBio 9:e01226-18, 2018, https://doi.org/10.1128/mBio.01226-18) report that phagosomal neutralization results from disruption of phagosomal membrane integrity by the enlarging hyphae, directly implicating the morphological transition in physical damage that promotes intracellular survival. The C. albicans intracellular strategy shows parallels with another fungal pathogen, Cryptococcus neoformans, where a morphological changed involving capsular enlargement intracellularly is associated with loss of membrane integrity and death of the host cell. These similarities among distantly related pathogenic fungi suggest that morphological transitions that are common in fungi directly affect the outcome of the fungal cell-macrophage interaction. For this class of organisms, form determines fate in the intracellular environment.

AB - For pathogenic microbes to survive ingestion by macrophages, they must subvert powerful microbicidal mechanisms within the phagolysosome. After ingestion, Candida albicans undergoes a morphological transition producing hyphae, while the surrounding phagosome exhibits a loss of phagosomal acidity. However, how these two events are related has remained enigmatic. Now Westman et al. (mBio 9:e01226-18, 2018, https://doi.org/10.1128/mBio.01226-18) report that phagosomal neutralization results from disruption of phagosomal membrane integrity by the enlarging hyphae, directly implicating the morphological transition in physical damage that promotes intracellular survival. The C. albicans intracellular strategy shows parallels with another fungal pathogen, Cryptococcus neoformans, where a morphological changed involving capsular enlargement intracellularly is associated with loss of membrane integrity and death of the host cell. These similarities among distantly related pathogenic fungi suggest that morphological transitions that are common in fungi directly affect the outcome of the fungal cell-macrophage interaction. For this class of organisms, form determines fate in the intracellular environment.

KW - Candida

KW - Cryptococcus

KW - fungus

KW - macrophage

KW - phagosome

U2 - 10.1128/mBio.02092-18

DO - 10.1128/mBio.02092-18

M3 - Article

C2 - 30352939

VL - 9

JO - mBio

JF - mBio

SN - 2150-7511

IS - 5

M1 - e02092-18

ER -