Improving metabolic flux predictions using absolute gene expression data

Dave Lee, Kieran Smallbone, Warwick B Dunn, Ettore Murabito, Catherine L Winder, Douglas B Kell, Pedro Mendes, Neil Swainston

Research output: Contribution to journalArticlepeer-review

88 Citations (Scopus)

Abstract

Constraint-based analysis of genome-scale metabolic models typically relies upon maximisation of a cellular objective function such as the rate or efficiency of biomass production. Whilst this assumption may be valid in the case of microorganisms growing under certain conditions, it is likely invalid in general, and especially for multicellular organisms, where cellular objectives differ greatly both between and within cell types. Moreover, for the purposes of biotechnological applications, it is normally the flux to a specific metabolite or product that is of interest rather than the rate of production of biomass per se.
Original languageEnglish
Pages (from-to)73
JournalBMC systems biology
Volume6
DOIs
Publication statusPublished - 2012

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