Importance of toxin A, toxin B, and CDT in virulence of an epidemic Clostridium difficile strain
Research output: Contribution to journal › Article
Colleges, School and Institutes
- Clostridia Research Group, Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, School of Life Sciences, University of Nottingham, United Kingdom.
Clostridium difficile infection is the main cause of healthcare-acquired diarrhea in the developed world. In addition to the main virulence factors toxin A and B, epidemic, PCR Ribotype 027 strains, such as R20291, produce a third toxin, CDT. To develop effective medical countermeasures, it is important to understand the importance of each toxin. Accordingly, we created all possible combinations of isogenic toxin mutants of R20291 and assessed their virulence. We demonstrated that either toxin A or toxin B alone can cause fulminant disease in the hamster infection model and present tantalizing data that C. difficile toxin may also contribute to virulence.
|Number of pages||4|
|Journal||The Journal of Infectious Diseases|
|Publication status||Published - 1 Jan 2014|
- ADP Ribose Transferases, Animals, Bacterial Proteins, Bacterial Toxins, Cell Death, Clostridium Infections, Clostridium difficile, Cricetinae, Enterotoxins, Female, HT29 Cells, Humans, Mesocricetus, Virulence, Journal Article, Research Support, Non-U.S. Gov't