Importance and assessment of quality of life in symptomatic permanent atrial fibrillation: Patient focus groups from the RATE-AF trial
Research output: Contribution to journal › Article › peer-review
Aims: To establish the extent and impact of symptoms in patients with atrial fibrillation (AF), the importance of different aspects of quality of life (QoL), and how we should assess wellbeing. Methods: Focus groups of patients with symptomatic permanent AF in a trial of heart rate control; the RATE-AF trial randomised 160 patients aged ≥60 years with permanent AF and at least NYHA class II dyspnoea to either digoxin or beta-blockers. Patient and public representatives led the focus groups and performed all data acquisition and analysis, using thematic approaches to interpret patient views about QoL and its measurement. Results: Substantial impairment of health-related QoL was noted in 160 trial patients, with impact on all domains apart from mental health. Eight women and 11 men aged 61–87 years participated in the focus groups. Common themes were a lack of information from healthcare professionals about AF, a lack of focus on QoL in consultations, and a sense of frustration, isolation, and reduced confidence. There was marked variability in symptoms in individual patients, with some describing severe impact on activities of daily living, and profound interaction with comorbidities such as arthritis. Day-to-day variation in QoL and difficulty in attributing symptom burden to AF or other comorbidities led to challenges in questionnaire completion. Consensus was reached that collecting both general and AF-specific QoL would be useful in routine practice, along with participation in peer support, which was empowering for the patients. Conclusions: The impact of comorbidities is poorly appreciated in the context of AF, with considerable variability in QoL that requires both generic and AF-specific assessment. Improvement in QoL should direct the appraisal, and reappraisal, of treatment decisions for patients with permanent AF.
Funding Information: This mixed methods study was part of the RATE-AF trial programme, a prospective, open-label, blinded endpoint, randomised controlled trial of 160 patients with symptomatic permanent AF. The trial is the first to directly compare longer-term heart rate con- trol using digoxin and beta-blocker therapy in this patient group (clinicaltrials.gov: NCT02391337, ISRCTN: 95259705, and Eu-draCT: 2015-005043-13). The rationale and design of the study have previously been described ; in brief, the trial was embedded within the UK National Health Service (NHS), with minimal selection criteria to reflect routine clinical care. Patients were aged 60 years or older, with permanent AF, in need of rate control, and breathlessness equivalent to at least New York Heart Association (NYHA) class II. As per guidelines, permanent AF was characterised as a physician decision for rate control with no plans for car-dioversion, antiarrhythmic drugs, or ablation . We only excluded patients with either clear requirements or contraindications for either drug, for example myocardial infarction in the last 6 months, a history of severe bronchospasm, bradycardia, or previous intolerance. The RATE-AF trial and the qualitative aspects were sponsored by the University of Birmingham and funded by the UK National Institute for Health Research (NIHR).
|Number of pages||10|
|Publication status||Published - 28 Aug 2020|