Implication of bisphosphonate use in the treatment of SAPHO syndrome: Case report and discussion of current literature

Patricia Gorecki; Philipp Stockmann; Jörg H.w. Distler; Wolfgang Wuest; Daniela Schmidt; Friedrich Wilhelm Neukam; Emeka Nkenke; Falk Wehrhan

doi:10.1016/j.jmhi.2015.04.002

Implication of bisphosphonate use in the treatment of SAPHO syndrome: Case report and discussion of current literature

Patricia Gorecki, Philipp Stockmann, Jörg H.w. Distler, Wolfgang Wuest, Daniela Schmidt, Friedrich Wilhelm Neukam, Emeka Nkenke, Falk Wehrhan

Dentistry

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Abstract

Even though increasing knowledge is emerging about synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome its pathogenesis remains enigmatic. Women are preferentially affected by SAPHO syndrome. Here we present the case of a 39-year-old woman suffering from this syndrome whose bone involvement was first interpreted as diffuse sclerosing osteomyelitis of the mandible. As treatment with clindamycin did not improve the symptoms, the decision was made to administer bisphosphonates intravenously. This treatment led to a rapid improvement in symptoms, which could be explained by the apparent tendency of bisphosphonates to exert a positive effect on the jaw. With this case report we attempt to offer an explanation for the influence of this group of medications on patients suffering from SAPHO syndrome with mandibular involvement.

Original language	English
Pages (from-to)	72-78
Number of pages	7
Journal	Journal of Medical Hypotheses and Ideas
Volume	9
Issue number	2
Early online date	25 Apr 2015
DOIs	https://doi.org/10.1016/j.jmhi.2015.04.002
Publication status	Published - 1 Dec 2015

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10.1016/j.jmhi.2015.04.002

Gorecki_et_al_Implication_bisphosphonate_use_Journal_Medical_Hypotheses_and_Ideas_2015
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title = "Implication of bisphosphonate use in the treatment of SAPHO syndrome: Case report and discussion of current literature",

abstract = "Even though increasing knowledge is emerging about synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome its pathogenesis remains enigmatic. Women are preferentially affected by SAPHO syndrome. Here we present the case of a 39-year-old woman suffering from this syndrome whose bone involvement was first interpreted as diffuse sclerosing osteomyelitis of the mandible. As treatment with clindamycin did not improve the symptoms, the decision was made to administer bisphosphonates intravenously. This treatment led to a rapid improvement in symptoms, which could be explained by the apparent tendency of bisphosphonates to exert a positive effect on the jaw. With this case report we attempt to offer an explanation for the influence of this group of medications on patients suffering from SAPHO syndrome with mandibular involvement.",

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T1 - Implication of bisphosphonate use in the treatment of SAPHO syndrome: Case report and discussion of current literature

AU - Gorecki, Patricia

AU - Stockmann, Philipp

AU - Distler, Jörg H.w.

AU - Wuest, Wolfgang

AU - Schmidt, Daniela

AU - Neukam, Friedrich Wilhelm

AU - Nkenke, Emeka

AU - Wehrhan, Falk

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Even though increasing knowledge is emerging about synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome its pathogenesis remains enigmatic. Women are preferentially affected by SAPHO syndrome. Here we present the case of a 39-year-old woman suffering from this syndrome whose bone involvement was first interpreted as diffuse sclerosing osteomyelitis of the mandible. As treatment with clindamycin did not improve the symptoms, the decision was made to administer bisphosphonates intravenously. This treatment led to a rapid improvement in symptoms, which could be explained by the apparent tendency of bisphosphonates to exert a positive effect on the jaw. With this case report we attempt to offer an explanation for the influence of this group of medications on patients suffering from SAPHO syndrome with mandibular involvement.

AB - Even though increasing knowledge is emerging about synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome its pathogenesis remains enigmatic. Women are preferentially affected by SAPHO syndrome. Here we present the case of a 39-year-old woman suffering from this syndrome whose bone involvement was first interpreted as diffuse sclerosing osteomyelitis of the mandible. As treatment with clindamycin did not improve the symptoms, the decision was made to administer bisphosphonates intravenously. This treatment led to a rapid improvement in symptoms, which could be explained by the apparent tendency of bisphosphonates to exert a positive effect on the jaw. With this case report we attempt to offer an explanation for the influence of this group of medications on patients suffering from SAPHO syndrome with mandibular involvement.

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DO - 10.1016/j.jmhi.2015.04.002

M3 - Article

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JO - Journal of Medical Hypotheses and Ideas

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Implication of bisphosphonate use in the treatment of SAPHO syndrome: Case report and discussion of current literature

Abstract

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