Impaired inhibitory processing: a new therapeutic target for autism and psychosis?

Research output: Contribution to journalArticlepeer-review


Colleges, School and Institutes

External organisations

  • Psychiatry and Youth Mental Health. Institute for Mental Health
  • Radboud Universiteit
  • Edgbaston Physiotherapy Clinic
  • University of Oxford
  • University College Dublin


In the healthy brain, homeostatic balance between excitation and inhibition maintains neural stability. Reduced inhibition may explain shared symptoms observed in autism and psychosis. Here we review evidence suggesting that altered levels of gamma-aminobutyric acid (GABA) may underlie both disorders, providing a potential cross-diagnostic therapeutic target.


Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalBritish Journal of Psychiatry
Publication statusE-pub ahead of print - 23 Oct 2020