TY - JOUR
T1 - Impaired B-1 adn B-2 B cell development adn atypical splenic B cell structures in IL-7 receptor-deficient mice
AU - Erlandsson, L
AU - Licence, S
AU - Gaspal, Fabrina
AU - Bell, S
AU - Lane, Peter
AU - Corcoran, AE
AU - Martensson, IL
PY - 2004/1/1
Y1 - 2004/1/1
N2 - The cytokine IL-7 and its receptor are essential for normal B and T lymphopoiesis. We have analyzed the role of this receptor in B cell development throughout ontogeny in IL-7 receptor alpha-deficient mice. We demonstrate that the IL-7 receptor becomes progressively more important with age. B lymphopoiesis takes place, albeit at reduced levels, in fetal liver and bone marrow of young mice, but is arrested in adults. The outcome is a severe reduction, from an early age, in peripheral B cells including follicular, marginal zone and B-1 B cells as well as perturbed splenic B cell structures, which are restored after adoptive transfer of normal spleen cells. We conclude that in the absence of the IL-7 receptor, the residual B lymphopoiesis occurring early in ontogeny must be facilitated by another component, whereas the IL-7 receptor is the key factor in adults. The impairment of marginal zone and B-1 B cells in IL-7 receptor- but not IL-7-deficient mice suggests non-redundant functions for the IL-7 receptor ligands, IL-7 and thymic stromal lymphopoietin.
AB - The cytokine IL-7 and its receptor are essential for normal B and T lymphopoiesis. We have analyzed the role of this receptor in B cell development throughout ontogeny in IL-7 receptor alpha-deficient mice. We demonstrate that the IL-7 receptor becomes progressively more important with age. B lymphopoiesis takes place, albeit at reduced levels, in fetal liver and bone marrow of young mice, but is arrested in adults. The outcome is a severe reduction, from an early age, in peripheral B cells including follicular, marginal zone and B-1 B cells as well as perturbed splenic B cell structures, which are restored after adoptive transfer of normal spleen cells. We conclude that in the absence of the IL-7 receptor, the residual B lymphopoiesis occurring early in ontogeny must be facilitated by another component, whereas the IL-7 receptor is the key factor in adults. The impairment of marginal zone and B-1 B cells in IL-7 receptor- but not IL-7-deficient mice suggests non-redundant functions for the IL-7 receptor ligands, IL-7 and thymic stromal lymphopoietin.
KW - B lymphopoiesis
KW - marginal zone B cells
KW - follicular B cells
KW - B-1 cells
KW - IL-7R
UR - http://www.scopus.com/inward/record.url?scp=10944229170&partnerID=8YFLogxK
U2 - 10.1002/eji.200425217
DO - 10.1002/eji.200425217
M3 - Article
C2 - 15495160
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
SN - 1521-4141
VL - 34
SP - 3595
JO - European Journal of Immunology
JF - European Journal of Immunology
ER -