Impact of Right Ventricular Dysfunction on Mortality in Patients Hospitalized With COVID-19, According to Race

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Impact of Right Ventricular Dysfunction on Mortality in Patients Hospitalized With COVID-19, According to Race. / Moody, William E; Mahmoud-Elsayed, Hani M; Senior, Jonathan; Gul, Uzma; Khan-Kheil, Ayisha M; Horne, Sebastian; Banerjee, Amitava; Bradlow, William M; Huggett, Robert; Hothi, Sandeep S; Shahid, Muhammad; Steeds, Richard P.

In: CJC open, Vol. 3, No. 1, 01.2021, p. 91-100.

Research output: Contribution to journalArticlepeer-review

Harvard

Moody, WE, Mahmoud-Elsayed, HM, Senior, J, Gul, U, Khan-Kheil, AM, Horne, S, Banerjee, A, Bradlow, WM, Huggett, R, Hothi, SS, Shahid, M & Steeds, RP 2021, 'Impact of Right Ventricular Dysfunction on Mortality in Patients Hospitalized With COVID-19, According to Race', CJC open, vol. 3, no. 1, pp. 91-100. https://doi.org/10.1016/j.cjco.2020.09.016

APA

Moody, W. E., Mahmoud-Elsayed, H. M., Senior, J., Gul, U., Khan-Kheil, A. M., Horne, S., Banerjee, A., Bradlow, W. M., Huggett, R., Hothi, S. S., Shahid, M., & Steeds, R. P. (2021). Impact of Right Ventricular Dysfunction on Mortality in Patients Hospitalized With COVID-19, According to Race. CJC open, 3(1), 91-100. https://doi.org/10.1016/j.cjco.2020.09.016

Vancouver

Author

Moody, William E ; Mahmoud-Elsayed, Hani M ; Senior, Jonathan ; Gul, Uzma ; Khan-Kheil, Ayisha M ; Horne, Sebastian ; Banerjee, Amitava ; Bradlow, William M ; Huggett, Robert ; Hothi, Sandeep S ; Shahid, Muhammad ; Steeds, Richard P. / Impact of Right Ventricular Dysfunction on Mortality in Patients Hospitalized With COVID-19, According to Race. In: CJC open. 2021 ; Vol. 3, No. 1. pp. 91-100.

Bibtex

@article{9bd8015f2c7d46e094558386546e1601,
title = "Impact of Right Ventricular Dysfunction on Mortality in Patients Hospitalized With COVID-19, According to Race",
abstract = "Background: Epidemiologic studies suggest that Black, Asian, and minority ethnic (BAME) patients may be at risk of worse outcomes from coronavirus disease-2019 (COVID-19), but the pathophysiological drivers for this association are unknown. This study sought to investigate the relationship between findings on echocardiography, mortality, and race in COVID-19 pneumonia. Methods: This was a multicentre, retrospective, observational study including 164 adults (aged 61 ± 13 years; 78% male; 36% BAME) hospitalized with COVID-19 undergoing echocardiography between March 16 and May 9, 2020 at 3 days (interquartile range 2-5) from admission. The primary outcome was all-cause mortality. Results: After a median follow-up of 31 days (interquartile range 14-42 days), 66 (40%) patients had died. The right ventricle was dilated in 62 (38%) patients, and 58 (35%) patients had right ventricular (RV) systolic dysfunction. Only 2 (1%) patients had left ventricular (LV) dilatation, and 133 (81%) had normal or hyperdynamic LV systolic function. Reduced tricuspid annulus planar systolic excursion was associated with elevated D-dimer (ρ = −0.18, P = 0.025) and high-sensitivity cardiac Troponin (ρ = −0.30, P < 0.0001). Reduced RV systolic function (hazard ratio 1.80; 95% confidence interval, 1.05-3.09; P = 0.032) was an independent predictor of all-cause mortality after adjustment for demographic and clinical risk factors. Comparing white and BAME individuals, there were no differences in echocardiography findings, biomarkers, or mortality. Conclusions: In patients hospitalized with COVID-19 pneumonia, reduced RV systolic function is prevalent and associated with all-cause mortality. There is, however, no racial variation in the early findings on echocardiography, biomarkers, or mortality.",
author = "Moody, {William E} and Mahmoud-Elsayed, {Hani M} and Jonathan Senior and Uzma Gul and Khan-Kheil, {Ayisha M} and Sebastian Horne and Amitava Banerjee and Bradlow, {William M} and Robert Huggett and Hothi, {Sandeep S} and Muhammad Shahid and Steeds, {Richard P}",
note = "Funding Information: This study was supported by a British Heart Foundation Accelerator Award, UK ( BHF AA/18/2/34218 ). Publisher Copyright: {\textcopyright} 2020 Canadian Cardiovascular Society",
year = "2021",
month = jan,
doi = "10.1016/j.cjco.2020.09.016",
language = "English",
volume = "3",
pages = "91--100",
journal = "CJC open",
issn = "2589-790X",
number = "1",

}

RIS

TY - JOUR

T1 - Impact of Right Ventricular Dysfunction on Mortality in Patients Hospitalized With COVID-19, According to Race

AU - Moody, William E

AU - Mahmoud-Elsayed, Hani M

AU - Senior, Jonathan

AU - Gul, Uzma

AU - Khan-Kheil, Ayisha M

AU - Horne, Sebastian

AU - Banerjee, Amitava

AU - Bradlow, William M

AU - Huggett, Robert

AU - Hothi, Sandeep S

AU - Shahid, Muhammad

AU - Steeds, Richard P

N1 - Funding Information: This study was supported by a British Heart Foundation Accelerator Award, UK ( BHF AA/18/2/34218 ). Publisher Copyright: © 2020 Canadian Cardiovascular Society

PY - 2021/1

Y1 - 2021/1

N2 - Background: Epidemiologic studies suggest that Black, Asian, and minority ethnic (BAME) patients may be at risk of worse outcomes from coronavirus disease-2019 (COVID-19), but the pathophysiological drivers for this association are unknown. This study sought to investigate the relationship between findings on echocardiography, mortality, and race in COVID-19 pneumonia. Methods: This was a multicentre, retrospective, observational study including 164 adults (aged 61 ± 13 years; 78% male; 36% BAME) hospitalized with COVID-19 undergoing echocardiography between March 16 and May 9, 2020 at 3 days (interquartile range 2-5) from admission. The primary outcome was all-cause mortality. Results: After a median follow-up of 31 days (interquartile range 14-42 days), 66 (40%) patients had died. The right ventricle was dilated in 62 (38%) patients, and 58 (35%) patients had right ventricular (RV) systolic dysfunction. Only 2 (1%) patients had left ventricular (LV) dilatation, and 133 (81%) had normal or hyperdynamic LV systolic function. Reduced tricuspid annulus planar systolic excursion was associated with elevated D-dimer (ρ = −0.18, P = 0.025) and high-sensitivity cardiac Troponin (ρ = −0.30, P < 0.0001). Reduced RV systolic function (hazard ratio 1.80; 95% confidence interval, 1.05-3.09; P = 0.032) was an independent predictor of all-cause mortality after adjustment for demographic and clinical risk factors. Comparing white and BAME individuals, there were no differences in echocardiography findings, biomarkers, or mortality. Conclusions: In patients hospitalized with COVID-19 pneumonia, reduced RV systolic function is prevalent and associated with all-cause mortality. There is, however, no racial variation in the early findings on echocardiography, biomarkers, or mortality.

AB - Background: Epidemiologic studies suggest that Black, Asian, and minority ethnic (BAME) patients may be at risk of worse outcomes from coronavirus disease-2019 (COVID-19), but the pathophysiological drivers for this association are unknown. This study sought to investigate the relationship between findings on echocardiography, mortality, and race in COVID-19 pneumonia. Methods: This was a multicentre, retrospective, observational study including 164 adults (aged 61 ± 13 years; 78% male; 36% BAME) hospitalized with COVID-19 undergoing echocardiography between March 16 and May 9, 2020 at 3 days (interquartile range 2-5) from admission. The primary outcome was all-cause mortality. Results: After a median follow-up of 31 days (interquartile range 14-42 days), 66 (40%) patients had died. The right ventricle was dilated in 62 (38%) patients, and 58 (35%) patients had right ventricular (RV) systolic dysfunction. Only 2 (1%) patients had left ventricular (LV) dilatation, and 133 (81%) had normal or hyperdynamic LV systolic function. Reduced tricuspid annulus planar systolic excursion was associated with elevated D-dimer (ρ = −0.18, P = 0.025) and high-sensitivity cardiac Troponin (ρ = −0.30, P < 0.0001). Reduced RV systolic function (hazard ratio 1.80; 95% confidence interval, 1.05-3.09; P = 0.032) was an independent predictor of all-cause mortality after adjustment for demographic and clinical risk factors. Comparing white and BAME individuals, there were no differences in echocardiography findings, biomarkers, or mortality. Conclusions: In patients hospitalized with COVID-19 pneumonia, reduced RV systolic function is prevalent and associated with all-cause mortality. There is, however, no racial variation in the early findings on echocardiography, biomarkers, or mortality.

UR - http://www.scopus.com/inward/record.url?scp=85097046971&partnerID=8YFLogxK

U2 - 10.1016/j.cjco.2020.09.016

DO - 10.1016/j.cjco.2020.09.016

M3 - Article

C2 - 32984798

VL - 3

SP - 91

EP - 100

JO - CJC open

JF - CJC open

SN - 2589-790X

IS - 1

ER -