Impact of exercise on cardiometabolic component risks in spinal cord injured humans

Research output: Contribution to journalArticlepeer-review

Authors

Colleges, School and Institutes

Abstract

Purpose: Spinal cord injury (SCI) creates a complex pathology, characterised by low levels of habitual physical activity and an increased risk of cardiometabolic disease. This study aimed to assess the impact of a moderate-intensity upper-body exercise training intervention on, biomarkers of cardiometabolic component risks, adipose tissue metabolism and cardiorespiratory fitness in persons with SCI. 

Methods: Twenty-one inactive men and women with chronic (>1 year) SCI (all paraplegic injuries), aged 47 ± 8 years (mean ± S.D), were randomly allocated to either a 6-week prescribed home-based exercise intervention (INT; n = 13) or control group (CON; n = 8). Participants assigned to the exercise group completed 4 x 45-min moderate-intensity (60-65% peak oxygen uptake (V̇˙O2peak)) arm-crank exercise sessions per week. At baseline and follow-up, fasted and post-load blood samples (collected during oral glucose tolerance tests) were obtained to measure metabolic regulation and biomarkers of cardiovascular disease. Abdominal subcutaneous adipose tissue biopsies were also obtained and cardiorespiratory fitness assessed.

Results: Compared with CON, INT significantly decreased (P = 0.04) serum fasting insulin (Δ, 3.1 ± 10.7 pmol·L−1 for CON and −12.7 ± 18.7 pmol·L−1 for INT) and homeostasis model assessment of insulin resistance (HOMA2-IR; Δ, 0.06 ± 0.20 for CON and −0.23 ± 0.36 for INT). The exercise group also increased V˙O2peak (Δ, 3.4 mL·kg−1·min−1; P ≤ 0.001). Adipose tissue metabolism, composite insulin sensitivity index (C-ISIMatsuda), and other cardiovascular disease risk biomarkers were not different between groups.

Conclusion: Moderate-intensity upper-body exercise improved aspects of metabolic regulation and cardiorespiratory fitness. Changes in fasting insulin and HOMA2-IR, but not C-ISIMatsuda, suggest improved hepatic but not peripheral insulin sensitivity following 6 weeks of exercise training in persons with chronic paraplegia.

Details

Original languageEnglish
Pages (from-to)2469-2477
Number of pages9
JournalMedicine and Science in Sports and Exercise
Volume49
Issue number12
Publication statusPublished - 31 Dec 2017

Keywords

  • Cardiovascular Fitness, Gene Expression, Insulin Sensitivity, Metabolic Health, Moderate-Intensity Exercise, Paraplegia