Impact of co-morbid attention-deficit and hyperactivity disorder on cognitive function in male children with Tourette syndrome: A controlled study

Research output: Contribution to journalArticlepeer-review

Standard

Impact of co-morbid attention-deficit and hyperactivity disorder on cognitive function in male children with Tourette syndrome: A controlled study. / Termine, Cristiano; Luoni, Chiara; Fontolan, Stefania; Selvini, Claudia; Perego, Livia; Pavone, Francesca; Rossi, Giorgio; Balottin, Umberto; Cavanna, Andrea E.

In: Psychiatry Research, Vol. 243, 01.09.2016, p. 263-267.

Research output: Contribution to journalArticlepeer-review

Harvard

APA

Vancouver

Author

Termine, Cristiano ; Luoni, Chiara ; Fontolan, Stefania ; Selvini, Claudia ; Perego, Livia ; Pavone, Francesca ; Rossi, Giorgio ; Balottin, Umberto ; Cavanna, Andrea E. / Impact of co-morbid attention-deficit and hyperactivity disorder on cognitive function in male children with Tourette syndrome: A controlled study. In: Psychiatry Research. 2016 ; Vol. 243. pp. 263-267.

Bibtex

@article{96916e32d2dc4306a97589a78b9c1e22,
title = "Impact of co-morbid attention-deficit and hyperactivity disorder on cognitive function in male children with Tourette syndrome: A controlled study",
abstract = "Tourette syndrome (TS) and attention-deficit and hyperactivity disorder (ADHD) are co-morbid neurodevelopmental conditions affecting more commonly male patients. We set out to determine the impact of co-morbid ADHD on cognitive function in male children with TS by conducting a controlled study. Participants included four matched groups of unmedicated children (age range 6–15 years): TS (n=13), TS+ADHD (n=8), ADHD (n=39), healthy controls (n=66). Following clinical assessment, each participant completed a battery of tests from the Wechsler Intelligence Scale for Children-III, the Italian Battery for ADHD, the Tower of London test, the Corsi test, and the Digit Span test. All patient groups reported significantly lower scores than healthy controls across the neuropsychological tests involving executive functions. The TS+ADHD group was the most severely affected, followed by the ADHD group and the TS group, particularly in the tests assessing planning ability, inhibitory function, working memory and visual attention, but not auditory attention. Problems in executive functions are more common in patients with neurodevelopmental disorders than controls. Deficits in planning ability, inhibitory function, working memory and visual attention reported by children with TS appear to be more strongly related to the presence of co-morbid ADHD symptoms than core TS symptoms.",
keywords = "Tourette syndrome, Tics, Attention-deficit and hyperactivity syndrome, Cognition, Executive functions",
author = "Cristiano Termine and Chiara Luoni and Stefania Fontolan and Claudia Selvini and Livia Perego and Francesca Pavone and Giorgio Rossi and Umberto Balottin and Cavanna, {Andrea E.}",
year = "2016",
month = sep,
day = "1",
doi = "10.1016/j.psychres.2016.06.048",
language = "English",
volume = "243",
pages = "263--267",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Impact of co-morbid attention-deficit and hyperactivity disorder on cognitive function in male children with Tourette syndrome: A controlled study

AU - Termine, Cristiano

AU - Luoni, Chiara

AU - Fontolan, Stefania

AU - Selvini, Claudia

AU - Perego, Livia

AU - Pavone, Francesca

AU - Rossi, Giorgio

AU - Balottin, Umberto

AU - Cavanna, Andrea E.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Tourette syndrome (TS) and attention-deficit and hyperactivity disorder (ADHD) are co-morbid neurodevelopmental conditions affecting more commonly male patients. We set out to determine the impact of co-morbid ADHD on cognitive function in male children with TS by conducting a controlled study. Participants included four matched groups of unmedicated children (age range 6–15 years): TS (n=13), TS+ADHD (n=8), ADHD (n=39), healthy controls (n=66). Following clinical assessment, each participant completed a battery of tests from the Wechsler Intelligence Scale for Children-III, the Italian Battery for ADHD, the Tower of London test, the Corsi test, and the Digit Span test. All patient groups reported significantly lower scores than healthy controls across the neuropsychological tests involving executive functions. The TS+ADHD group was the most severely affected, followed by the ADHD group and the TS group, particularly in the tests assessing planning ability, inhibitory function, working memory and visual attention, but not auditory attention. Problems in executive functions are more common in patients with neurodevelopmental disorders than controls. Deficits in planning ability, inhibitory function, working memory and visual attention reported by children with TS appear to be more strongly related to the presence of co-morbid ADHD symptoms than core TS symptoms.

AB - Tourette syndrome (TS) and attention-deficit and hyperactivity disorder (ADHD) are co-morbid neurodevelopmental conditions affecting more commonly male patients. We set out to determine the impact of co-morbid ADHD on cognitive function in male children with TS by conducting a controlled study. Participants included four matched groups of unmedicated children (age range 6–15 years): TS (n=13), TS+ADHD (n=8), ADHD (n=39), healthy controls (n=66). Following clinical assessment, each participant completed a battery of tests from the Wechsler Intelligence Scale for Children-III, the Italian Battery for ADHD, the Tower of London test, the Corsi test, and the Digit Span test. All patient groups reported significantly lower scores than healthy controls across the neuropsychological tests involving executive functions. The TS+ADHD group was the most severely affected, followed by the ADHD group and the TS group, particularly in the tests assessing planning ability, inhibitory function, working memory and visual attention, but not auditory attention. Problems in executive functions are more common in patients with neurodevelopmental disorders than controls. Deficits in planning ability, inhibitory function, working memory and visual attention reported by children with TS appear to be more strongly related to the presence of co-morbid ADHD symptoms than core TS symptoms.

KW - Tourette syndrome

KW - Tics

KW - Attention-deficit and hyperactivity syndrome

KW - Cognition

KW - Executive functions

U2 - 10.1016/j.psychres.2016.06.048

DO - 10.1016/j.psychres.2016.06.048

M3 - Article

VL - 243

SP - 263

EP - 267

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

ER -