Impact of change in the United Kingdom pediatric donor organ allocation policy for intestinal transplantation.

Research output: Contribution to journalArticle

Authors

  • M Giovanelli
  • GL Gupte
  • Patrick McKiernan
  • P Pocock
  • C Lloyd
  • K Sharif
  • DA Mayer
  • Darius Mirza

Colleges, School and Institutes

Abstract

BACKGROUND Graft availability remains a problem in pediatric intestinal transplantation (IT), with most children waiting being less than 10 kg weight. In November 2004, wait-listed children in the United Kingdom were prioritized nationally to receive pediatric donor organs to improve donor availability for IT. We aimed to evaluate the impact of this change on the recipient population. METHODS Data regarding pediatric donor organ availability and allocation were accessed from the National Transplant database. Recipient demographics and outcomes were recorded from the Liver Unit database. Between 2001 and 2006, there were 228 pediatric donors in the United Kingdom (nonheart-beating donors were excluded), of which 39 livers were allocated to emergency super-urgent liver candidates. A total of six isolated intestine and 21 liver-intestine transplants (15 reduced size, six full grafts) were performed in the same period. RESULTS Since January 2001, there has been a progressive reduction in overall pediatric organ donation. Increasing awareness about IT has resulted in a significant increase in number of small bowel organs being offered (71.8% vs. 19.5%), although this has been associated with an increase in referrals for transplantation. Despite an increase in number of IT being performed (2.6 vs. 7.7 mean transplants per year), waiting list mortality still remains high in smaller children (

Details

Original languageEnglish
Pages (from-to)1695-9
Number of pages5
JournalTransplantation
Volume87
Issue number11
Publication statusPublished - 15 Jun 2009