Immunologic unresponsiveness to alloantigen in vivo: a role for regulatory T cells

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Immunologic unresponsiveness to alloantigen in vivo : a role for regulatory T cells. / Wood, Kathryn J; Bushell, Andrew; Jones, Nick D.

In: Immunological Reviews, Vol. 241, No. 1, 05.2011, p. 119-32.

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Wood, Kathryn J ; Bushell, Andrew ; Jones, Nick D. / Immunologic unresponsiveness to alloantigen in vivo : a role for regulatory T cells. In: Immunological Reviews. 2011 ; Vol. 241, No. 1. pp. 119-32.

Bibtex

@article{33802d8e191240b68b21193f655d1aae,
title = "Immunologic unresponsiveness to alloantigen in vivo: a role for regulatory T cells",
abstract = "Exposure to alloantigen in vivo or in vitro induces alloantigen reactive regulatory T cells that can control transplant rejection. The mechanisms that underpin the activity of alloantigen reactive regulatory T cells in vivo are common with those of regulatory T cells that prevent autoimmunity. The identification and characterization of regulatory T cells that control rejection and contribute to the induction of immunologic unresponsiveness to alloantigens in vivo has opened up exciting opportunities for new therapies in transplantation. Findings from laboratory studies are informing the design of clinical protocols using regulatory T cells as a cellular therapy.",
keywords = "Animals, T-Lymphocytes, Regulatory, Isoantigens, Graft Rejection, Humans, Immunotherapy, Adoptive, Autoimmunity, Immune Tolerance, Organ Transplantation, Clinical Protocols",
author = "Wood, {Kathryn J} and Andrew Bushell and Jones, {Nick D}",
note = "{\textcopyright} 2011 John Wiley & Sons A/S.",
year = "2011",
month = may,
doi = "10.1111/j.1600-065X.2011.01013.x",
language = "English",
volume = "241",
pages = "119--32",
journal = "Immunological Reviews",
issn = "0105-2896",
publisher = "Wiley",
number = "1",

}

RIS

TY - JOUR

T1 - Immunologic unresponsiveness to alloantigen in vivo

T2 - a role for regulatory T cells

AU - Wood, Kathryn J

AU - Bushell, Andrew

AU - Jones, Nick D

N1 - © 2011 John Wiley & Sons A/S.

PY - 2011/5

Y1 - 2011/5

N2 - Exposure to alloantigen in vivo or in vitro induces alloantigen reactive regulatory T cells that can control transplant rejection. The mechanisms that underpin the activity of alloantigen reactive regulatory T cells in vivo are common with those of regulatory T cells that prevent autoimmunity. The identification and characterization of regulatory T cells that control rejection and contribute to the induction of immunologic unresponsiveness to alloantigens in vivo has opened up exciting opportunities for new therapies in transplantation. Findings from laboratory studies are informing the design of clinical protocols using regulatory T cells as a cellular therapy.

AB - Exposure to alloantigen in vivo or in vitro induces alloantigen reactive regulatory T cells that can control transplant rejection. The mechanisms that underpin the activity of alloantigen reactive regulatory T cells in vivo are common with those of regulatory T cells that prevent autoimmunity. The identification and characterization of regulatory T cells that control rejection and contribute to the induction of immunologic unresponsiveness to alloantigens in vivo has opened up exciting opportunities for new therapies in transplantation. Findings from laboratory studies are informing the design of clinical protocols using regulatory T cells as a cellular therapy.

KW - Animals

KW - T-Lymphocytes, Regulatory

KW - Isoantigens

KW - Graft Rejection

KW - Humans

KW - Immunotherapy, Adoptive

KW - Autoimmunity

KW - Immune Tolerance

KW - Organ Transplantation

KW - Clinical Protocols

U2 - 10.1111/j.1600-065X.2011.01013.x

DO - 10.1111/j.1600-065X.2011.01013.x

M3 - Article

C2 - 21488894

VL - 241

SP - 119

EP - 132

JO - Immunological Reviews

JF - Immunological Reviews

SN - 0105-2896

IS - 1

ER -