Immune responses to Epstein-Barr virus: molecular interactions in the virus evasion of CD8(+) T cell immunity

Research output: Contribution to journalReview articlepeer-review

Colleges, School and Institutes

Abstract

Persistent viruses have mechanisms for modulating the host immune responses that are essential for achieving a lifelong virus–host balance while minimizing the viral pathogenicity. Here we review some of the immune-modulating mechanisms evolved by the ubiquitous but potentially oncogenic Epstein–Barr virus, with particular emphasis on the molecular mechanisms of genes interfering with HLA class I antigen presentation

Details

Original languageEnglish
Pages (from-to)173-181
Number of pages9
JournalMicrobes and Infection
Volume12
Issue number3
Publication statusPublished - 1 Mar 2010

Keywords

  • Immune-evasion, Tumour virus, Epstein-Barr virus, Herpesvirus, Immune response, Antigen presentation