Immobilisation of proteins by atomic clusters on surfaces

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Immobilisation of proteins by atomic clusters on surfaces. / Palmer, Richard; Leung, Carl.

In: Trends in Biotechnology, Vol. 25, 01.02.2007, p. 48-55.

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@article{2a3e856321ed4d7494c6845e984a8e13,
title = "Immobilisation of proteins by atomic clusters on surfaces",
abstract = "In this Opinion article, we describe a nanotechnology-based approach to immobilize and orient proteins onto surfaces using atomic clusters prepared by physical methods. This is relevant to future protein biochips where dilute arrays of protein binding sites, each designed to immobilize no more than one protein molecule, would be ideal. In the case of a surface consisting of size-selected atomic gold clusters, proteins containing free cysteine residues can chemisorb directly to the bare cluster surface, thus effecting oriented immobilisation. The selection of atomic gold clusters in the size range 1-100 atoms (",
author = "Richard Palmer and Carl Leung",
year = "2007",
month = feb,
day = "1",
doi = "10.1016/j.tibtech.2006.12.004",
language = "English",
volume = "25",
pages = "48--55",
journal = "Trends in Biotechnology",
issn = "0167-7799",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Immobilisation of proteins by atomic clusters on surfaces

AU - Palmer, Richard

AU - Leung, Carl

PY - 2007/2/1

Y1 - 2007/2/1

N2 - In this Opinion article, we describe a nanotechnology-based approach to immobilize and orient proteins onto surfaces using atomic clusters prepared by physical methods. This is relevant to future protein biochips where dilute arrays of protein binding sites, each designed to immobilize no more than one protein molecule, would be ideal. In the case of a surface consisting of size-selected atomic gold clusters, proteins containing free cysteine residues can chemisorb directly to the bare cluster surface, thus effecting oriented immobilisation. The selection of atomic gold clusters in the size range 1-100 atoms (

AB - In this Opinion article, we describe a nanotechnology-based approach to immobilize and orient proteins onto surfaces using atomic clusters prepared by physical methods. This is relevant to future protein biochips where dilute arrays of protein binding sites, each designed to immobilize no more than one protein molecule, would be ideal. In the case of a surface consisting of size-selected atomic gold clusters, proteins containing free cysteine residues can chemisorb directly to the bare cluster surface, thus effecting oriented immobilisation. The selection of atomic gold clusters in the size range 1-100 atoms (

U2 - 10.1016/j.tibtech.2006.12.004

DO - 10.1016/j.tibtech.2006.12.004

M3 - Review article

C2 - 17173994

VL - 25

SP - 48

EP - 55

JO - Trends in Biotechnology

JF - Trends in Biotechnology

SN - 0167-7799

ER -