Imaging workflow and calibration for CT-guided time-domain fluorescence tomography

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Imaging workflow and calibration for CT-guided time-domain fluorescence tomography. / Tichauer, KM; Holt, RW; El-Ghussein, F; Zhu, Qun; Dehghani, Hamid; Leblond, F; Pogue, BW.

In: Biomedical Optics Express, Vol. 2, No. 11, 01.01.2011, p. 3021-3036.

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Tichauer, KM ; Holt, RW ; El-Ghussein, F ; Zhu, Qun ; Dehghani, Hamid ; Leblond, F ; Pogue, BW. / Imaging workflow and calibration for CT-guided time-domain fluorescence tomography. In: Biomedical Optics Express. 2011 ; Vol. 2, No. 11. pp. 3021-3036.

Bibtex

@article{2ec6a23f1fbf4ae6ab26c53e68fddb05,
title = "Imaging workflow and calibration for CT-guided time-domain fluorescence tomography",
abstract = "In this study, several key optimization steps are outlined for a non-contact, time-correlated single photon counting small animal optical tomography system, using simultaneous collection of both fluorescence and transmittance data. The system is presented for time-domain image reconstruction in vivo, illustrating the sensitivity from single photon counting and the calibration steps needed to accurately process the data. In particular, laser time- and amplitude-referencing, detector and filter calibrations, and collection of a suitable instrument response function are all presented in the context of time-domain fluorescence tomography and a fully automated workflow is described. Preliminary phantom time-domain reconstructed images demonstrate the fidelity of the workflow for fluorescence tomography based on signal from multiple time gates.",
author = "KM Tichauer and RW Holt and F El-Ghussein and Qun Zhu and Hamid Dehghani and F Leblond and BW Pogue",
year = "2011",
month = jan
day = "1",
doi = "10.1364/BOE.2.003021",
language = "English",
volume = "2",
pages = "3021--3036",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "Optical Society of America",
number = "11",

}

RIS

TY - JOUR

T1 - Imaging workflow and calibration for CT-guided time-domain fluorescence tomography

AU - Tichauer, KM

AU - Holt, RW

AU - El-Ghussein, F

AU - Zhu, Qun

AU - Dehghani, Hamid

AU - Leblond, F

AU - Pogue, BW

PY - 2011/1/1

Y1 - 2011/1/1

N2 - In this study, several key optimization steps are outlined for a non-contact, time-correlated single photon counting small animal optical tomography system, using simultaneous collection of both fluorescence and transmittance data. The system is presented for time-domain image reconstruction in vivo, illustrating the sensitivity from single photon counting and the calibration steps needed to accurately process the data. In particular, laser time- and amplitude-referencing, detector and filter calibrations, and collection of a suitable instrument response function are all presented in the context of time-domain fluorescence tomography and a fully automated workflow is described. Preliminary phantom time-domain reconstructed images demonstrate the fidelity of the workflow for fluorescence tomography based on signal from multiple time gates.

AB - In this study, several key optimization steps are outlined for a non-contact, time-correlated single photon counting small animal optical tomography system, using simultaneous collection of both fluorescence and transmittance data. The system is presented for time-domain image reconstruction in vivo, illustrating the sensitivity from single photon counting and the calibration steps needed to accurately process the data. In particular, laser time- and amplitude-referencing, detector and filter calibrations, and collection of a suitable instrument response function are all presented in the context of time-domain fluorescence tomography and a fully automated workflow is described. Preliminary phantom time-domain reconstructed images demonstrate the fidelity of the workflow for fluorescence tomography based on signal from multiple time gates.

U2 - 10.1364/BOE.2.003021

DO - 10.1364/BOE.2.003021

M3 - Article

C2 - 22076264

VL - 2

SP - 3021

EP - 3036

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 11

ER -