Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography

Ben Brooksby; Brian W Pogue; Shudong Jiang; Hamid Dehghani; Subhadra Srinivasan; Christine Kogel; Tor D Tosteson; John Weaver; Steven P Poplack; Keith D Paulsen

doi:10.1073/pnas.0509636103

Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography

Ben Brooksby, Brian W Pogue, Shudong Jiang, Hamid Dehghani, Subhadra Srinivasan, Christine Kogel, Tor D Tosteson, John Weaver, Steven P Poplack, Keith D Paulsen

Computer Science

Research output: Contribution to journal › Article › peer-review

209 Citations (Scopus)

Abstract

Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.

Original language	English
Pages (from-to)	8828-33
Number of pages	6
Journal	National Academy of Sciences. Proceedings
Volume	103
Issue number	23
DOIs	https://doi.org/10.1073/pnas.0509636103
Publication status	Published - 6 Jun 2006

Keywords

Adipose Tissue
Aged
Breast
Female
Hemoglobins
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Middle Aged
Spectroscopy, Near-Infrared
Tomography

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10.1073/pnas.0509636103

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Brooksby, B., Pogue, B. W., Jiang, S., Dehghani, H., Srinivasan, S., Kogel, C., Tosteson, T. D., Weaver, J., Poplack, S. P., & Paulsen, K. D. (2006). Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography. National Academy of Sciences. Proceedings, 103(23), 8828-33. https://doi.org/10.1073/pnas.0509636103

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title = "Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography",

abstract = "Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.",

keywords = "Adipose Tissue, Aged, Breast, Female, Hemoglobins, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Middle Aged, Spectroscopy, Near-Infrared, Tomography",

author = "Ben Brooksby and Pogue, {Brian W} and Shudong Jiang and Hamid Dehghani and Subhadra Srinivasan and Christine Kogel and Tosteson, {Tor D} and John Weaver and Poplack, {Steven P} and Paulsen, {Keith D}",

year = "2006",

month = jun,

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doi = "10.1073/pnas.0509636103",

language = "English",

volume = "103",

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journal = "National Academy of Sciences. Proceedings",

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Brooksby, B, Pogue, BW, Jiang, S, Dehghani, H, Srinivasan, S, Kogel, C, Tosteson, TD, Weaver, J, Poplack, SP & Paulsen, KD 2006, 'Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography', National Academy of Sciences. Proceedings, vol. 103, no. 23, pp. 8828-33. https://doi.org/10.1073/pnas.0509636103

TY - JOUR

T1 - Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography

AU - Brooksby, Ben

AU - Pogue, Brian W

AU - Jiang, Shudong

AU - Dehghani, Hamid

AU - Srinivasan, Subhadra

AU - Kogel, Christine

AU - Tosteson, Tor D

AU - Weaver, John

AU - Poplack, Steven P

AU - Paulsen, Keith D

PY - 2006/6/6

Y1 - 2006/6/6

N2 - Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.

AB - Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.

KW - Adipose Tissue

KW - Aged

KW - Breast

KW - Female

KW - Hemoglobins

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Middle Aged

KW - Spectroscopy, Near-Infrared

KW - Tomography

U2 - 10.1073/pnas.0509636103

DO - 10.1073/pnas.0509636103

M3 - Article

C2 - 16731633

SN - 0027-8424

VL - 103

SP - 8828

EP - 8833

JO - National Academy of Sciences. Proceedings

JF - National Academy of Sciences. Proceedings

IS - 23

ER -

Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography

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Keywords

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