Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography

Research output: Contribution to journalArticlepeer-review


  • Ben Brooksby
  • Brian W Pogue
  • Shudong Jiang
  • Subhadra Srinivasan
  • Christine Kogel
  • Tor D Tosteson
  • John Weaver
  • Steven P Poplack
  • Keith D Paulsen

Colleges, School and Institutes


Magnetic resonance (MR)-guided near-infrared spectral tomography was developed and used to image adipose and fibroglandular breast tissue of 11 normal female subjects, recruited under an institutional review board-approved protocol. Images of hemoglobin, oxygen saturation, water fraction, and subcellular scattering were reconstructed and show that fibroglandular fractions of both blood and water are higher than in adipose tissue. Variation in adipose and fibroglandular tissue composition between individuals was not significantly different across the scattered and dense breast categories. Combined MR and near-infrared tomography provides fundamental molecular information about these tissue types with resolution governed by MR T1 images.


Original languageEnglish
Pages (from-to)8828-33
Number of pages6
JournalNational Academy of Sciences. Proceedings
Issue number23
Publication statusPublished - 6 Jun 2006


  • Adipose Tissue, Aged, Breast, Female, Hemoglobins, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Middle Aged, Spectroscopy, Near-Infrared, Tomography