Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size

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Image-guided optical spectroscopy provides molecular-specific information in vivo : MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size. / Carpenter, Colin M; Pogue, Brian W; Jiang, Shudong; Dehghani, Hamid; Wang, Xin; Paulsen, Keith D; Wells, Wendy A; Forero, Jorge; Kogel, Christine; Weaver, John B; Poplack, Steven P; Kaufman, Peter A.

In: Optics Letters, Vol. 32, No. 8, 15.04.2007, p. 933-5.

Research output: Contribution to journalArticle

Harvard

Carpenter, CM, Pogue, BW, Jiang, S, Dehghani, H, Wang, X, Paulsen, KD, Wells, WA, Forero, J, Kogel, C, Weaver, JB, Poplack, SP & Kaufman, PA 2007, 'Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size', Optics Letters, vol. 32, no. 8, pp. 933-5.

APA

Carpenter, C. M., Pogue, B. W., Jiang, S., Dehghani, H., Wang, X., Paulsen, K. D., Wells, W. A., Forero, J., Kogel, C., Weaver, J. B., Poplack, S. P., & Kaufman, P. A. (2007). Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size. Optics Letters, 32(8), 933-5.

Vancouver

Author

Carpenter, Colin M ; Pogue, Brian W ; Jiang, Shudong ; Dehghani, Hamid ; Wang, Xin ; Paulsen, Keith D ; Wells, Wendy A ; Forero, Jorge ; Kogel, Christine ; Weaver, John B ; Poplack, Steven P ; Kaufman, Peter A. / Image-guided optical spectroscopy provides molecular-specific information in vivo : MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size. In: Optics Letters. 2007 ; Vol. 32, No. 8. pp. 933-5.

Bibtex

@article{82e289cf3ac84cae9d1a4dc272e2146b,
title = "Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size",
abstract = "A multimodality instrument that integrated optical or near-infrared spectroscopy into a magnetic resonance imaging (MRI) breast coil was used to perform a pilot study of image-guided spectroscopy on cancerous breast tissue. These results are believed to be the first multiwavelength spectroscopic images of breast cancer using MRI-guided constraints, and they show the cancer tumor to have high hemoglobin and water values, decreased oxygen saturation, and increased subcellular granularity. The use of frequency-domain diffuse tomography methods at many wavelengths provides the spectroscopy required for recovering maps of absorbers and scattering spectra, but the integration with MRI allows these data to be recovered on an image field that preserves high resolution and fuses the two data sets together. Integration of molecular spectroscopy into standard clinical MRI can be achieved with this approach to spectral tomography.",
keywords = "Adult, Breast Neoplasms, Carcinoma, Ductal, Breast, Female, Hemoglobins, Humans, Magnetic Resonance Imaging, Oxygen, Spectroscopy, Near-Infrared, Water",
author = "Carpenter, {Colin M} and Pogue, {Brian W} and Shudong Jiang and Hamid Dehghani and Xin Wang and Paulsen, {Keith D} and Wells, {Wendy A} and Jorge Forero and Christine Kogel and Weaver, {John B} and Poplack, {Steven P} and Kaufman, {Peter A}",
year = "2007",
month = apr
day = "15",
language = "English",
volume = "32",
pages = "933--5",
journal = "Optics Letters",
issn = "0146-9592",
publisher = "Optical Society of America",
number = "8",

}

RIS

TY - JOUR

T1 - Image-guided optical spectroscopy provides molecular-specific information in vivo

T2 - MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size

AU - Carpenter, Colin M

AU - Pogue, Brian W

AU - Jiang, Shudong

AU - Dehghani, Hamid

AU - Wang, Xin

AU - Paulsen, Keith D

AU - Wells, Wendy A

AU - Forero, Jorge

AU - Kogel, Christine

AU - Weaver, John B

AU - Poplack, Steven P

AU - Kaufman, Peter A

PY - 2007/4/15

Y1 - 2007/4/15

N2 - A multimodality instrument that integrated optical or near-infrared spectroscopy into a magnetic resonance imaging (MRI) breast coil was used to perform a pilot study of image-guided spectroscopy on cancerous breast tissue. These results are believed to be the first multiwavelength spectroscopic images of breast cancer using MRI-guided constraints, and they show the cancer tumor to have high hemoglobin and water values, decreased oxygen saturation, and increased subcellular granularity. The use of frequency-domain diffuse tomography methods at many wavelengths provides the spectroscopy required for recovering maps of absorbers and scattering spectra, but the integration with MRI allows these data to be recovered on an image field that preserves high resolution and fuses the two data sets together. Integration of molecular spectroscopy into standard clinical MRI can be achieved with this approach to spectral tomography.

AB - A multimodality instrument that integrated optical or near-infrared spectroscopy into a magnetic resonance imaging (MRI) breast coil was used to perform a pilot study of image-guided spectroscopy on cancerous breast tissue. These results are believed to be the first multiwavelength spectroscopic images of breast cancer using MRI-guided constraints, and they show the cancer tumor to have high hemoglobin and water values, decreased oxygen saturation, and increased subcellular granularity. The use of frequency-domain diffuse tomography methods at many wavelengths provides the spectroscopy required for recovering maps of absorbers and scattering spectra, but the integration with MRI allows these data to be recovered on an image field that preserves high resolution and fuses the two data sets together. Integration of molecular spectroscopy into standard clinical MRI can be achieved with this approach to spectral tomography.

KW - Adult

KW - Breast Neoplasms

KW - Carcinoma, Ductal, Breast

KW - Female

KW - Hemoglobins

KW - Humans

KW - Magnetic Resonance Imaging

KW - Oxygen

KW - Spectroscopy, Near-Infrared

KW - Water

M3 - Article

C2 - 17375158

VL - 32

SP - 933

EP - 935

JO - Optics Letters

JF - Optics Letters

SN - 0146-9592

IS - 8

ER -