IFN-α and IFN-β: a link between immune memory and chronic inflammation

AN Akbar; Janet Lord; Michael Salmon

doi:10.1016/S0167-5699(00)01652-2

IFN-α and IFN-β: a link between immune memory and chronic inflammation

AN Akbar, Janet Lord, Michael Salmon

Immunology and Immunotherapy

Research output: Contribution to journal › Article

118 Citations (Scopus)

Abstract

The majority of expanded T cells generated during an immune response are cleared by apoptosis. Prevention of death in some activated T cells enables the persistence of a memory T-cell pool. Here, observations that IFN-alpha and IFN-beta inhibit activated T-cell apoptosis are described. Although this enables memory T cells to persist without antigen, excessive IFN-alpha or IFN-gamma secretion might lead to chronic inflammation.

Original language	English
Pages (from-to)	337-342
Number of pages	6
Journal	Immunology Today
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/S0167-5699(00)01652-2
Publication status	Published - 1 Jul 2000

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abstract = "The majority of expanded T cells generated during an immune response are cleared by apoptosis. Prevention of death in some activated T cells enables the persistence of a memory T-cell pool. Here, observations that IFN-alpha and IFN-beta inhibit activated T-cell apoptosis are described. Although this enables memory T cells to persist without antigen, excessive IFN-alpha or IFN-gamma secretion might lead to chronic inflammation.",

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AB - The majority of expanded T cells generated during an immune response are cleared by apoptosis. Prevention of death in some activated T cells enables the persistence of a memory T-cell pool. Here, observations that IFN-alpha and IFN-beta inhibit activated T-cell apoptosis are described. Although this enables memory T cells to persist without antigen, excessive IFN-alpha or IFN-gamma secretion might lead to chronic inflammation.

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IFN-α and IFN-β: a link between immune memory and chronic inflammation

Abstract

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