IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studying isocitrate dehydrogenase (IDH) mutations since their discovery just over a year ago. In a recent study published in Nature, Dang et al. identified 2-hydroxyglutarate as a product of tumor-associated IDH mutants with potential oncogenic activities.

Details

Original languageEnglish
Pages (from-to)7-9
Number of pages3
JournalCancer Cell
Volume17
Issue number1
Publication statusPublished - 1 Jan 2010