IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip

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Colleges, School and Institutes


The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studying isocitrate dehydrogenase (IDH) mutations since their discovery just over a year ago. In a recent study published in Nature, Dang et al. identified 2-hydroxyglutarate as a product of tumor-associated IDH mutants with potential oncogenic activities.


Original languageEnglish
Pages (from-to)7-9
Number of pages3
JournalCancer Cell
Issue number1
Publication statusPublished - 1 Jan 2010