IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip

C Frezza; Daniel Tennant; E Gottlieb

doi:10.1016/j.ccr.2009.12.031

IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip

C Frezza, Daniel Tennant, E Gottlieb

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studying isocitrate dehydrogenase (IDH) mutations since their discovery just over a year ago. In a recent study published in Nature, Dang et al. identified 2-hydroxyglutarate as a product of tumor-associated IDH mutants with potential oncogenic activities.

Original language	English
Pages (from-to)	7-9
Number of pages	3
Journal	Cancer Cell
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/j.ccr.2009.12.031
Publication status	Published - 1 Jan 2010

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10.1016/j.ccr.2009.12.031

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title = "IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip",

abstract = "The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studying isocitrate dehydrogenase (IDH) mutations since their discovery just over a year ago. In a recent study published in Nature, Dang et al. identified 2-hydroxyglutarate as a product of tumor-associated IDH mutants with potential oncogenic activities.",

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AB - The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studying isocitrate dehydrogenase (IDH) mutations since their discovery just over a year ago. In a recent study published in Nature, Dang et al. identified 2-hydroxyglutarate as a product of tumor-associated IDH mutants with potential oncogenic activities.

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JO - Cancer Cell

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IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip

Abstract

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