Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease

Research output: Contribution to journalArticle

Authors

  • M. Medici
  • E. Porcu
  • G. Pistis
  • A. Teumer
  • S.J. Brown
  • R.A. Jensen
  • R. Rawal
  • G.L. Roef
  • T.S. Plantinga
  • S.H. Vermeulen
  • J. Lahti
  • M.J. Simmonds
  • L.L.N. Husemoen
  • R.M. Freathy
  • B.M. Shields
  • D. Pietzner
  • R. Nagy
  • L. Broer
  • L. Chaker
  • T.I.M. Korevaar
  • M.G. Plia
  • C. Sala
  • U. Völker
  • J.B. Richards
  • F.C. Sweep
  • C. Gieger
  • T. Corre
  • E. Kajantie
  • B. Thuesen
  • Y.E. Taes
  • W.E. Visser
  • A.T. Hattersley
  • J. Kratzsch
  • A. Hamilton
  • W. Li
  • G. Homuth
  • M. Lobina
  • S. Mariotti
  • N. Soranzo
  • M. Cocca
  • M. Nauck
  • C. Spielhagen
  • A. Ross
  • A. Arnold
  • M. van de Bunt
  • S. Liyanarachchi
  • M. Heier
  • H.J. Grabe
  • C. Masciullo
  • T.E. Galesloot
  • E.M. Lim
  • E. Reischl
  • P.J. Leedman
  • S. Lai
  • A. Delitala
  • A.P. Bremner
  • D.I.W. Philips
  • J.P. Beilby
  • A. Mulas
  • M. Vocale
  • G. Abecasis
  • T. Forsen
  • A. James
  • E. Widen
  • J. Hui
  • H. Prokisch
  • E.E. Rietzschel
  • A. Palotie
  • P. Feddema
  • S.J. Fletcher
  • K. Schramm
  • J.I. Rotter
  • A. Kluttig
  • D. Radke
  • M. Traglia
  • G.L. Surdulescu
  • H. He
  • D. Tiller
  • B. Vaidya
  • T. de Meyer
  • T. Jørgensen
  • J.G. Eriksson
  • P.C. O'Leary
  • E. Wichmann
  • A.R. Hermus
  • B.M. Psaty
  • T. Ittermann
  • A. Hofman
  • E. Bosi
  • D. Schlessinger
  • H. Wallaschofski
  • N. Pirastu
  • Y.S. Aulchenko
  • A. de la Chapelle
  • R.T. Netea-Maier
  • S.C.L. Gough
  • H. Meyer zu Schwabedissen
  • T.M. Frayling
  • J.-M. Kaufman
  • A. Linneberg
  • K. Räikkönen
  • J.W.A. Smit
  • L.A. Kiemeney
  • F. Rivadeneira
  • A.G. Uitterlinden
  • J.P. Walsh
  • C. Meisinger
  • M. den Heijer
  • T.J. Visser
  • T.D. Spector
  • S.G. Wilson
  • H. Völzke
  • A. Cappola
  • D. Toniolo
  • S. Sanna
  • S. Naitza
  • R.P. Peeters

Colleges, School and Institutes

Abstract

Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoimmune hyperthyroidism (Graves' disease). As the possible causative genes of TPOAbs and AITD remain largely unknown, we performed GWAS meta-analyses in 18,297 individuals for TPOAb-positivity (1769 TPOAb-positives and 16,528 TPOAb-negatives) and in 12,353 individuals for TPOAb serum levels, with replication in 8,990 individuals. Significant associations (P

Details

Original languageEnglish
Article numbere1004123
JournalPLoS Genetics
Volume10
Issue number2
Publication statusPublished - 27 Feb 2014

Keywords

  • thyroid peroxidase antibody, thyrotropin, adult, aged, antibody blood level, article, ATXN2 gene, autoimmune disease, autoimmune thyroid disease, autoimmunity, Bach2 gene, cancer risk, controlled study, female, gene, gene frequency, gene identification, gene locus, genetic association, genetic variability, goiter, Graves disease, Hashimoto disease, human, kalrn gene, MAGI3 gene, major clinical study, male, risk assessment, risk factor, risk reduction, scoring system, single nucleotide polymorphism, subclinical hyperthyroidism, subclinical hypothyroidism, thyroid cancer, thyroid disease, TPO gene