Identification of a TAP-independent immunoproteasome-dependent CD8+ T-cell epitope in the Epstein-Barr virus latent membrane protein 2
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Colleges, School and Institutes
We have identified an HLA-A2-restricted CD8(+) T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but uniquely is dependent upon the immunoproteasome for its generation.
|Number of pages||5|
|Journal||Journal of virology|
|Publication status||Published - 15 Feb 2003|