Identification of a TAP-independent immunoproteasome-dependent CD8+ T-cell epitope in the Epstein-Barr virus latent membrane protein 2

Research output: Contribution to journalArticle

Authors

  • Tracey Haigh
  • S Mayrhofer
  • Deborah Croom-Carter
  • Alison Leese
  • S Gadola
  • V Cerundolo

Colleges, School and Institutes

Abstract

We have identified an HLA-A2-restricted CD8(+) T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but uniquely is dependent upon the immunoproteasome for its generation.

Details

Original languageEnglish
Pages (from-to)2757-2761
Number of pages5
JournalJournal of virology
Volume77
Issue number4
Publication statusPublished - 15 Feb 2003