Projects per year
Abstract
Despite the importance of Salmonella infections in human and animal health, the target antigens of Salmonella-specific immunity remain poorly defined. We have previously shown evidence for antibody-mediating protection against invasive Salmonellosis in mice and African children. To generate an overview of antibody targeting in systemic Salmonellosis, a Salmonella proteomic array containing over 2,700 proteins was constructed and probed with immune sera from Salmonella-infected mice and humans. Analysis of multiple inbred mouse strains identified 117 antigens recognized by systemic antibody responses in murine Salmonellosis. Importantly, many of these antigens were independently identified as target antigens using sera from Malawian children with Salmonella bacteremia, validating the study of the murine model. Furthermore, vaccination with SseB, the most prominent antigenic target in Malawian children, provided mice with significant protection against Salmonella infection. Together, these data uncover an overlapping immune signature of disseminated Salmonellosis in mice and humans and provide a foundation for the generation of a protective subunit vaccine.
Original language | English |
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Pages (from-to) | 4998-5003 |
Number of pages | 6 |
Journal | National Academy of Sciences. Proceedings |
Volume | 109 |
Issue number | 13 |
DOIs | |
Publication status | Published - 1 Mar 2012 |
Keywords
- non-Typhi Salmonella bacteremia
- antigen discovery
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Dive into the research topics of 'Identification of a common immune signature in murine and human systemic Salmonellosis'. Together they form a unique fingerprint.Projects
- 1 Finished
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MRC Centre For Immune Regulation (Linked to DCDF.RRAK10540) (Linked to 14810 & 14835)
Jenkinson, E.
3/08/09 → 30/09/17
Project: Research Councils